Mutations in the “Hot Spots” of the FLT3, NPM1, IDH1, IDH2 and DNMT3A Genes in Acute Myeloid Leukemia

The purpose of the study was to systematize and present up-to-date data on the prevalence, combination and clinical significance of mutations in the “hot spots” of the FLT3, NPM1, IDH1, IDH2, DNMT3A genes in acute myeloid leukemia (AML). Material and Methods. A search was conducted for available domestic and foreign literary sources published in the PubMed and RSCI database over the past 10 years. 509 sources were found. Publications such as “Letters to the Editor” and “Comments” on published works, animal and cell model studies, as well as works on secondary AML, AML/myelodysplastic syndrome were excluded from the analysis. Mostly more recent works with the full text of the publication available in Russian or English were used. As a result, 66 papers were included in this article. The results of high-performance sequencing AML samples (1567 adults and 144 children) presented in the C-Bioportal for cancer genomics database (C-Bioportal) were analyzed.