Impairment of the melatonergic system in the pathophysiology of diabetic encephalopathy (review)

Objective: to analyze the scientific literature to identify the main pathophysiological mechanisms of melatonergic system disorders in the formation of diabetic encephalopathy and to highlight the possible therapeutic efficacy of melatonin (MLT). Review writing methodology. A total of 50 scientific papers were found using the Cochrane Library, PubMed, el_ibrary.ru, Medscape, and analyzed. Database search had been performed for papers published from2011 to 2023 using the keyword combination 'diabetesmellitus", "melatonergic system", "melatonin" and "diabetic encephalopathy".