Нарушение мелатонинергической системы в патофизиологии диабетической энцефалопатии (обзор)
Автор: Быков Ю.В.
Журнал: Саратовский научно-медицинский журнал @ssmj
Рубрика: Патологическая физиология
Статья в выпуске: 4 т.19, 2023 года.
Бесплатный доступ
Цель: провести анализ научной литературы для выявления основных патофизиологических механизмов нарушения мелатонинергической системы в формировании диабетической энцефалопатии и осветить возможную терапевтическую эффективность мелатонина (МЛТ). Методика написания обзора. Проанализированы 50 научных работ, размещенных в базах данных Cochrane Library, PubMed, eLibrary.ru, Medscape. Период электронного поиска - 2011-2023 гг., проводили с использованием комбинации ключевых слов: «diabetes mellitus», «melatonergic system», «melatonin» и «diabetic encephalopathy».
Апоптоз, воспаление, диабетическая энцефалопатия, мелатонин, оксидативный стресс, сахарный диабет
Короткий адрес: https://sciup.org/149144843
IDR: 149144843 | DOI: 10.15275/ssmj1904399
Список литературы Нарушение мелатонинергической системы в патофизиологии диабетической энцефалопатии (обзор)
- American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014; 37 (Suppl. 1): S81-S90. DOI:10.2337/dc14-S081
- Xiong L, Liu S, Liu C, et al. The protective effects of melatonin in high glucose environment by alleviating autophagy and apoptosis on primary cortical neurons. Mol Cell Biochem. 2023; 478 (7): 1415-25. DOI:10.1007/s11010-022-04596-w
- Быков Ю. В. Сахарный диабет I типа в педиатрической практике и поражения центральной нервной системы. Таврический медико-биологический вестник. 2020; 4 (23): 91-8.
- Pourhanifeh МН, Hosseinzadeh A, Dehdashtian Е et al. Melatonin: New insights on its therapeutic properties in diabetic complications. Diabetol Metab Syndr 2020; 12: 30. DOI:10.1186 /s13098-020-00537-z
- Guariguata L, Whiting DR, Hambleton I, et al. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 2014; 103 (2): 137-49. DOI:10.1016/j. diabres. 2013.11.002
- Sadeghi A, Hami J, Razavi S, et al. The effect of diabetes mellitus on apoptosis in hippocampus: Cellular and molecular aspects. Int J Prev Med. 2016; 7: 57. DOI:10.4103/2008-7802.178531
- Быков Ю.В. Оксидативный стресс и диабетическая энцефалопатия: патофизиологические механизмы. Современные проблемы науки и образования. 2022; 6-2: 39. DOI:10.17513/spno. 32314
- Быков Ю.В., Батурин В. А. Диабетическая энцефалопатия при сахарном диабете в детском возрасте: патофизиология и клинические проявления (обзор). Саратовский научно-медицинский журнал. 2022; 18 (1): 46-9.
- Ramos-Rodriguez JJ, Molina-Gil S, Ortiz-Barajas О, et al. Central proliferation and neurogenesis is impaired in type 2 diabetes and prediabetes animal models. PLoS One. 2014; 9 (2): e89229. DOI:10.1371/journal. pone. 0089229
- Vieira LL, de Lima Soares RG, Da Silva Felipe SM, et al. Physiological targets for the treatment of diabetic encephalopathy. Cent Nerv Syst Agents Med Chem. 2017; 17 (1): 78-86. PMID: 27121380
- Amin SN, Sharawy N, El Tablawy N, et al. Melatonin-Pretreated Mesenchymal Stem Cells Improved Cognition in a Diabetic Murine Model. Front Physiol. 2021; 12: 628107. DOI:10.3389/fphys.2021.628107
- Kor Y, Geyikli I, Keskin M, Akan M. Preliminary study: Evaluation of melatonin secretion in children and adolescents with type 1 diabetes mellitus. Indian J Endocrinol Metab. 2014; 18 (4): 565-8. DOI:10.4103/2230-8210.137521
- Shen QH, Li HF, Zhou XY, et al. Relation of serum melatonin levels to postoperative delirium in older patients undergoing major abdominal surgery. J Int Med Res. 2020; 48 (3): 300060520910642. DOI:10.1177/0300060520910642
- Karamitri A, Jockers R. Melatonin in type 2 diabetes mellitus and obesity. Nat Rev Endocrinol. 2019; 15 (2): 105-25. DOM 0.1038/S41574-018-0130-1
- De Berardis D, Marini S, Fornaro M, et al. The melatonergic system in mood and anxiety disorders and the role of agomelatine: implications for clinical practice. Int J Mol Sci. 2013; 14(6): 12458-83. DOI:10.3390/ijms140612458
- Мичурина СВ., Васендин Д.В., Ищенко Д. Ю. Физиологические и биологические эффекты мелатонина: некоторые итоги и перспективы изучения. Российский физиологический журнал им. И.М. Сеченова. 2018; 104(3): 257-71.
- Yu X, Li Z, Zheng H, et al. Protective roles of melatonin in central nervous system diseases by regulation of neural stem cells. Cell Prolif. 2017; 50: e12323. DOI:10.1111/cpr.12323
- Wu J, Tan Z, Li H, et al. Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O-GlcNAcylation of cyclin-dependent-like kinase 5. J Pineal Res. 2021; 71 (3):e12765. DOI:10.1111/jpi.12765
- Gurunathan S, Kang MH, Kim JH. Role and therapeutic potential of melatonin in the central nervous system and cancers. Cancers (Basel). 2020; 12 (6): 1567. DOI: 10.3390/cancers12061567
- Arjunan A, Sah DK, Jung YD, Song J. Hepatic encepha-lopathy and melatonin. Antioxidants (Basel). 2022; 11 (5): 837. DOI: 10.3390/antiox11050837
- Hsu MH, Chen YC, Sheen JM, et al. Melatonin prevented spatial deficits and increases in brain asymmetric dimethylargi-nine in young bile duct ligation rats. Neuroreport. 2018; 29: 541-6. DOI:10.1097/WNR. 0000000000000972
- Cui Y, Yang M, Wang Y, et al. Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway. FASEB J. 2021; 35 (4): e21485. DOM0.1096/fj. 202002247 RR
- Tchekalarova J, Nenchovska Z, Kortenska L, et al. Impact of melatonin deficit on emotional status and oxidative stress-induced changes in sphingomyelin and cholesterol level in young adult, mature, and aged rats. Int J Mol Sci. 2022; 23 (5): 2809. DOI:10.3390/ijms23052809
- Morvaridzadeh M, Sadeghi E, Agah S, et al. Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis. Pharmacol Res. 2020; 161: 105210. DOI:10.1016/j.phrs.2020.105210
- Mirza-Aghazadeh-Attari M, Mohammadzadeh A, Mostavafi S, et al. Melatonin: An important anticancer agent in colorectal cancer. J Cell Physiol. 2020; 235 (2): 804-17. DOI:10.1002/jcp.29049
- Maiocchi SL, Morris JC, Rees MD, Thomas SR. Regulation of the nitric oxide oxidase activity of myeloperoxidase by pharmacological agents. Biochem Pharmacol. 2017; (135): 90-115. DOI:10.1016/j.bcp.2017.03.016
- Jangra A, Datusalia AK, Khandwe S, Sharma SS. Amelioration of diabetes-induced neurobehavioral and neurochemical changes by melatonin and nicotinamide: implication of oxidative stress — PARP pathway. Pharmacol Biochem Behav. 2013; (114-115): 43-51. DOI:10.1016/j. pbb. 2013.10.021
- Hajam YA, Rai S, Roy A, et al. Repossession of brain complications in a streptozotocin induced diabetic rat by exogenous melatonin administration. Int J Zool Res. 2017; 13 (2): 64-73. DOI:10.3923/ijzr. 2017.64.73
- Sharma C, Kim S, Nam Y, et al. Mitochondrial dysfunction asa driver of cognitive impairment in Alzheimer's disease. Int J Mol Sci. 2021; 22 (9): 4850. DOI:10.3390/ijms22094850
- Reiter RJ, Ma Q, Sharma R, et al. Melatonin in mitochondria: Mitigating clear and present dangers. Physiology (Bethes-da). 2020; 35 (2): 86-95. DOI:10.1152/physiol. 00034.2019
- Chen WR, Liu HB, Chen YD, et al. Melatonin attenuates myocardial ischemia/reperfusion injury by inhibiting autophagy via an AMPK/mTOR signaling pathway. Cell Physiol Biochem. 2018; 47 (5): 2067-76. DOI:10.1159/000491474
- Ganie SA, Dar ТА, Bhat AH, et al. Melatonin: A potential anti-oxidant therapeutic agent for mitochondrial dysfunctions and related disorders. Rejuvenation Res. 2016; 19 (1): 21-40. DOI:10.1089/rej. 2015.1704
- Muriach M, Flores-Bellver M, Romero FJ, Barcia JM. Diabetes and the brain: Oxidative stress, inflammation, and autophagy. Oxid Med Cell Longev. 2014;2014:102158. DOI:10.1155/2014/102158
- Chen L, Hu L, Zhao J, et al. Chotosan improves Ap 1-42-induced cognitive impairment and neuroinflammatory and apoptotic responses through the inhibition of TLR-4/NF-KB signaling in mice. Journal of Ethnopharmacology. 2016; 191: 398-407. DOI:10.1016/j.jep.2016.03.038
- Duman TT, Aktas G, Atak BM, et al. Neutrophil to lymphocyte ratio as an indicative of diabetic control level in type 2 diabetes mellitus. African Health Sciences. 2019; 19 (1): 1602-6. DOI:10.4314/ahs. V19M.35
- Sundberg I, Rasmusson AJ, Ramklint M, et al. Daytime melatonin levels in saliva are associated with inflammatory markers and anxiety disorders. Psychoneuroendocrinology. 2020; 112: 104514. DOI:10.1016/j.psyneuen.2019.104514
- Ortiz F, Acuna-Castroviejo D, Doerrier C, et al. Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis. J Pineal Res. 2015; 58 (1): 34-49. DOI:10.1111 /jpi.12191
- Permpoonputtana K, Govitrapong P. The antiinflammatory effect of melatonin on methamphetamine-induced proinflammatory mediators in human neuroblastoma dopa-mine SH-SY5Y cell lines. Neurotox Res. 2013; 23: 189-99. DOI:10.1007/sl 2640-012-9350-7
- Zarezadeh M, Khorshidi M, Emami M, et al. Melatonin supplementation and pro-inflammatory mediators: A systematic review and meta-analysis of clinical trials. European Journal of Nutrition. 2020; 59 (5): 1803-13. DOI:10.1007/s00394-019-02123-0
- Maher AM, Saleh SR, Elguindy NM, et al. Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats through attenuating indoleamine 2, 3-dioxygenase 1 expression. Life Sciences. 2020; (247): 117427. DOI:10.1016/j. Ifs.2020.117427
- Hardeland R. Aging, melatonin, and the pro- and anti-inflammatory networks. Int J Mol Sci. 2019; 20 (5): 1223. DOI:10.3390/ijms20051223
- Yuan H, Wu G, Zhai X, et al. Melatonin and rapamycin attenuate isoflurane-induced cognitive impairment through inhibition of neuroinflammation by suppressing the mTOR signaling in the hippocampus of aged mice. Front Aging Neurosci. 2019; 11: 314. DOI:10.3389/fnagi.2019.00314
- Yang B, Zhang LY, Chen Y, et al. Melatonin alleviates intestinal injury, neuroinflammation and cognitive dysfunction caused by intestinal ischemia/reperfusion. Int Immunopharma-col. 2020; 85: 106596. DOI:10.1016/j.intimp.2020.106596
- Bloemer J, Bhattacharya S, Amin R, Suppiramaniam V. Impaired insulin signaling and mechanisms of memory loss. Prog Mol Biol Transl Sci. 2014; 121: 413-49. DOI:10.1016/B978-0-12-800101-1.00013-2
- Sharma S, Singh H, Ahmad N, et al. The role of melatonin in diabetes: Therapeutic implications. Arch Endocrinol Metab. 2015; 59 (5): 391-9. DOI:10.1590/2359-3997000000098
- Wongchitrat P, Lansubsakul N, Kamsrijai U, et al. Melatonin attenuates the high-fat diet and streptozotocin-induced reduction in rat hippocampal neurogenesis. Neurochem Int. 2016; 100: 97-109. DOI:10.1016/j.neuint.2016.09.006
- Kamsrijai U, Wongchitrat P, Nopparat C, et al. Melatonin attenuates streptozotocin-induced Alzheimer-like features in hyperglycemic rats. Neurochem Int. 2020; 132: 104601. DOM 0.1016/j. neuint.2019.104601
- Radi E, Formichi P, Battisti C, Federico A. Apoptosis and oxidative stress in neurodegenerative diseases. J Alzheim-ers Dis. 2014; 42 Suppl. 3: S125-52. DOM 0.3233/JAD-132738
- Amer ME, Othamn Al, El-Missiry MA. Melatonin ameliorates diabetes-induced brain injury in rats. Acta Histochem. 2021; 123(2): 151677. DOI:10.1016/j.acthis.2020.151677
- Carrasco C, Rodriguez AB, Pariente JA. Melatonin as a stabilizer of mitochondrial function: Role in diseases and aging. Turk J Biol. 2015; 39(6): 822-31. DOI:10.3906/biy-1504-26