Radiation-induced oxidative stress depends on dysfunction of the mitochondrial biogenesis in the K562 cancer cell line

In this paper we study the dynamics and source of radiation-induced oxidative stress in cancer cells and evaluate the mitochondrial role in this process. Radiation-induced ROS generation in K562 cells has two time point peak 5 min – 1 h and 24-48 h. Increase in mitochondrial potential associated with an increase in intracellular mitochondrial mass can be called as a reason for increasing the concentration of radiation-induced ROS in a 24-48 hours after irradiation. Irradiation stimulates in K562 cells the catabolism of acetyl groups and oxidative phosphorylation gene expression, but reduces the expression of genes encoding proteins involved in mitochondrial biogenesis.