Inheritance of cytogenetic and molecular-cellular effects in cells of animals bone marrow at chronic impact of ionizing radiation

In experiments on laboratory mice effects of chronic influence of gamma radiation in the range of doses from 10 to 64 сGy are investigated. The nonmonotonic change of damages of DNA estimated on molecular (the DNA-cometary test) and cytogenetic levels (micronuclear test, a mitotic index) is shown. At the first generation of mice whose parents have been irradiated in doses 10, 20 and 30 сGy, authentically higher level of double-stranded ruptures of DNA, cells with micronuclei, decrease in mitotic activity and strengthening of apoptosis in comparison with control is noted. At the second or third the generations which are given rise from the parents irradiated in a dose 30 сGy in comparison with control authentically lower level of double- stranded ruptures of DNA and cells with micronuclei against the background of decrease in a mitotic index and apoptosis. At the fifth generation of distinction with control are leveled.