Hereditary mutations in Russian patients with early, family and bilateral breast cances
Автор: Sokolenko A.P., Rozanov M.E., Mityushkina N.V., Sherina N.Yu., Levleva A.G., Chekmareva E.V., Buslov K.G., Shilov E.S., Togo A.V., Bit-sava E.M., Voskresensky D.A., Chagunava O.L., Trofimov D.Yu., Kovalenko S.P., Devilee P., Cornelisse C., Semiglazov V.F., Imyanitov E.N.
Журнал: Сибирский онкологический журнал @siboncoj
Рубрика: Экспериментальные исследования
Статья в выпуске: 3 (27), 2008 года.
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Hereditary mutations can significantly contribute to predisposition to breast cancer. This study was undertaken to analyze 8 recurrent mutations in 302 breast cancer cases selected according to clinical signs of hereditary cancer (bilateral cancer and/or young age of disease occurrence (A in 2 (0.7%). Such mutations as BRCAl 185delAG, BRCA2 6174delT and NBS1 657del5 were detected each in one case. Mutation BRCAl 300T>G (C61G) was not detected. Most hereditary breast cancers in Russia can be diagnosed by means of a small number of PCR-tests.
Breast cancer, hereditary cancer, "founder" мутации, "founder" mutations
Короткий адрес: https://sciup.org/14054861
IDR: 14054861
