Hereditary diseases in the practice of a pathologist

Recent years have observed rapid rates of development in human genetics and medical genetics: more than 4,000 hereditary diseases have been studied. Hereditary pathology contributes much to child morbidity, mortality and disability, but it can also be found in adulthood. Geographical parameters greatly influence the prevalence of hereditary diseases. The objective of the study is to analyze hereditary diseases in the practice of a pathologist during the last 10-year period, analyzing the autopsies of Ulyanovsk Regional Clinical Hospital. Materials and Methods. In this study we examined genetic aspects, prevalence of hereditary diseases, macro and microscopic pictures of hereditary disease manifestations. We used ten-year autopsy and biopsy protocols of pathoanatomical department of Ulyanovsk Regional Clinical Hospital. The object of the study was surgical, biopsy, and sectional material taken from patients and persons deceased in Ulyanovsk Regional Clinical Hospital in 2005-2015. After routine histology, paraffin sections stained with hematoxylin and eosin were made. The authors carried out morphological analysis of histologic specimen and autopsy protocols using archival data of Ulyanovsk Regional Clinical Hospital pathoanatomical department. Results. Analyzing the incidence of hereditary diseases in the regional morbidity, we conclude that hereditary pathology is represented by a very wide range of diseases, including rare and atypical chromosome abnormalities. It is apparently caused by considerable ethnic heterogeneity of the Volga region; how-ever,hereditary pathology increases in the national morbidity structure.