Neurogenesis in the rat's brain of different ages subjected to the graduated exercise treatment (experimental and immunohistochemical study)

The results of histochemical evaluation of protein expression of GFAP, CD56 (NCAM) and Cyclin D1 in the brain tissue in rats of different ages when exposed to a regular physical activity are presented. Results. It is found that the exercise stress stimulated the neurogenesis in old and young animals, to a greater extent - in females. In young animals in control as well as in experimental group the neurogenesis was observed in the subependymal zone. During exercise neurogenesis was also observed in the hippocampus (in females). In the control group of old animals the neurogenesis was detected in the hippocampus in a small number of females. In older animals treated graduated physical stress, the new nerve cells formed in the subependymal zone - both in males and females, and in the ependyma - in females. However in older animals a certain part of the newly formed cells (in the dentate gyrus and hippocampus), is (можно was) apparently still differentiated towards in glial phenotype.