Нейровизуализации в клинике расстройств, связанных с употреблением психоактивных веществ (введение в проблему)

Автор: Асадуллин Азат Раилевич, Анцыборов Андрей Викторович, Ахметова Эльвина Аслямовна

Журнал: Сибирский вестник психиатрии и наркологии @svpin

Рубрика: Лекции. Обзоры

Статья в выпуске: 1 (98), 2018 года.

Бесплатный доступ

Проведенный анализ литературы, посвященной нейровизуальной картине головного мозга пациентов с наркотической зависимостью, позволяет сделать вывод о том, что практически у всех пациентов имеется дефицит нейрональных связей в отделах мозга, отвечающих за вознаграждение и импульсивность. В настоящем обзоре основное внимание уделено исследованиям, использующим позитронно-эмиссионную томографию (ПЭТ), функциональную магнитно-резонансную томографию (МРТ) и электроэнцефалографию (ЭЭГ) для исследования поведенческих нарушений у пациентов с наркотической зависимостью.

Дофамин, электроэнцефалография (ээг), магнитно-резонансная томография (мрт), позитронно-эмиссионная томография (пэт), префронтальная кора

Короткий адрес: https://sciup.org/142212925

IDR: 142212925   |   УДК: 616.89-008.441.33:612.82   |   DOI: 10.26617/1810-3111

Neuroimaging of the clinical picture of substance use disorders (introduction to the problem)

The analysis of the literature on the neuroimaging of the cerebral brain of patients with drug dependence suggests that virtually all patients have a deficit of neural connections, in the brain responsible for remuneration and impulsivity. This review focuses on studies using positron emission tomography (PET), functional magnetic resonance imaging (MRI), and electroencephalography (EEG) to investigate behavioral disorders in patients with drug dependence.

Список литературы Нейровизуализации в клинике расстройств, связанных с употреблением психоактивных веществ (введение в проблему)

  • Adams K.M. et al. The significance of family history status in relation to neuropsychological test performance and cerebral glucose metabolism studied with positron emission tomography in older alcoholic patients. Alcoholism: Clinical and Experimental Research. 1998; 22 (1): 105-110.
  • Anker J.J., Carroll M.E. Females are more vulnerable to drug abuse than males: evidence from preclinical studies and the role of ovarian hormones. Biological Basis of Sex Differences in Psychopharmacology. Springer Berlin Heidelberg, 2010: 73-96.
  • Bassareo V., De Luca M. A., Di Chiara G. Differential expression of motivational stimulus properties by dopamine in nucleus accumbens shell versus core and prefrontal cortex. Journal of neuroscience. 2002; 22 (11): 4709^719.
  • Bechara A. Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Nature neuroscience. 2005; 8 (11): 1458-1463.
  • Bonson K.R. et al. Neural systems and cue-induced cocaine craving. Neuropsychopharmacology. 2002. 26: 376-386 DOI: 10.1016/S0893-133X(01)00371-3712
  • Brody A.L. et al. Attenuation of cue-induced cigarette craving and anterior cingulate cortex activation in bupropion-treated smokers: a preliminary study. Psychiatry Research: Neuroimaging. 2004; 130 (3): 269-281.
  • Brody A. L. et al. Brain metabolic changes during cigarette craving. Archives of General Psychiatry. 2002; 59 (12): 1162-1172.
  • Buckley P. Association of Low Striatal Dopamine D2 Receptor Availability with Nicotine Dependence Similar to That Seen with Other Drugs of Abuse. Year Book of Psychiatry & Applied Mental Health. 2009; 2009: 324.
  • Cassens G. et al. Amphetamine withdrawal: effects on threshold of intracranial reinforcement. Psychopharmacology. 1981; 73 (4): 318-322.
  • Catafau A.M. et al. Regional cerebral blood flow changes in chronic alcoholic patients induced by naltrexone challenge during detoxification. Journal of Nuclear Medicine. 1999; 40 (1): 19.
  • Childress A.R. et al. Limbic activation during cue-induced cocaine craving. American Journal of Psychiatry. 1999; 156 (1): 11-18.
  • Cornish J.L., Duffy P., Kalivas P.W. A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior. Neuroscience. 1999; 93 (4): 1359-1367.
  • Courtney K.E., Polich J. Binge drinking effects on EEG in young adult humans. International journal of environmental research and public health. 2010; 7 (5): 2325-2336.
  • Daglish M.R.C. et al. Functional connectivity analysis of the neural circuits of opiate craving): "more" rather than "different"? Neuroimage. 2003; 20 (4): 1964-1970.
  • Daurignac E. et al. 522 Attentional withdrawal and smoking cessation): A longitudinal ERP study. International Journal of Psychophysiology. 1998; 30 (1-2): 201-202.
  • Di Chiara G. A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use. Journal of psychopharmacology. 1998; 12 (1): 54-67.
  • Domino E.F. Effects of tobacco smoking on electroencephalographic, auditory evoked and event related potentials. Brain and cognition. 2003; 53 (1): 66-74.
  • Due D. L. et al. Activation in mesolimbic and visuospatial neural circuits elicited by smoking cues): evidence from functional magnetic resonance imaging. American Journal of Psychiatry. 2002; 159 (6): 954-960.
  • Ehlers C.L., Schuckit M.A. EEG fast frequency activity in the sons of alcoholics. Biological psychiatry. 1990; 27 (6): 631-641.
  • Ehlers C.L., Wall T.L., Schuckit M.A. EEG spectral characteristics following ethanol administration in young men. Electroencephalography and Clinical Neurophysiology. 1989; 73 (3): 179-187.
  • Foltin R.W. et al. The effects of escalating doses of smoked cocaine in humans. Drug and AcoholDependence. 2003; 70 (2): 149-157.
  • Franken I.H.A. Drug craving and addiction): integrating psychological and neuropsychopharmacological approaches. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2003; 27 (4): 563-579.
  • Franklin T.R. et al. Limbic activation to cigarette smoking cues independent of nicotine withdrawal): a perfusion fMRI study. Neuropsychopharmacology. 2007; 32 (11): 2301-2309.
  • Gilman J.M. et al. Why we like to drink): a functional magnetic resonance imaging study of the rewarding and anxiolytic effects of alcohol. Journal of Neuroscience. 2008; 28 (18): 4583-4591.
  • Glenn S.W., Sinha R., Parsons O.A. Electrophysiological indices predict resumption of drinking in sober Alcoholics. Alcohol. 1993; 10 (2): 89-95.
  • Goldstein R.Z. et al. Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addiction. Proceedings of the National Academy of Sciences. 2009; 106 (23): 9453-9458.
  • Goldstein R.Z. et al. Dopaminergic response to drug words in cocaine addiction. Journal of Neuroscience. 2009; 29 (18): 6001-6006.
  • Goldstein R.Z. et al. Role of the anterior cingulate and medial orbitofrontal cortex in processing drug cues in cocaine addiction. Neuroscience. 2007; 144 (4): 1153-1159.
  • Goldstein R. Z., Volkow N. D. Drug addiction and its underlying neurobiological basis): neuroimaging evidence for the involvement of the frontal cortex. American Journal of Psychiatry. 2002; 159 (10): 1642-1652.
  • Gooding D. C., Burroughs S., Boutros N. N. Attentional deficits in cocaine-dependent patients): converging behavioral and electrophysiological evidence. Psychiatry Research. 2008; 160 (2): 145-154.
  • Grant S. et al. Activation of memory circuits during cue-elicited cocaine craving. Proceedings of the National Academy of Sciences. 1996; 93 (21): 12040-12045.
  • Grüsser S. M. et al. Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics. Psychopharmacology. 2004; 175 (3): 296-302.
  • Gu H. et al. Mesocorticolimbic circuits are impaired in chronic cocaine users as demonstrated by resting-state functional connectivity. Neuroimage. 2010; 53 (2): 593-601.
  • Heinz A., Siessmeier T., Wrase J. Correlation Between Dopamine D Receptors in the Ventral Striatum and Central Processing of Alcohol Cues and Craving. Year Book of Psychiatry & Applied Mental Health. 2006; 2006): 81-82.
  • Herning R.I. et al. Cocaine increases EEG beta): a replication and extension of Hans Berger's historic experiments. Electroencephalography and Clinical Neurophysiology. 1985; 60 (6): 470-477.
  • Herning R.I. et al. Cocaine-induced increases in EEG alpha and beta activity): evidence for reduced cortical processing. Neuropsychopharmacology. 1994; 11 (1): 1-9.
  • Herning R.I. et al. Neurophysiological signs of cocaine dependence): increased electroencephalogram beta during with drawal. Biological Psychiatry. 1997; 41 (11): 1087-1094. Нейровизуализации в клинике расстройств, связанных..
  • Herrmann M.J. et al. Event related potentials and cue reactivity in alcoholism. Alcoholism: Clinical and Experimental Research. 2000; 24 (11): 1724-1729.
  • Ingvar M. et al. Alcohol activates the cerebral reward system in man. Journal of Studies on Alcohol. 1998; 59 (3): 258-269.
  • Kilts C.D. et al. Neural activity related to drug craving in cocaine addiction. Archives of General Psychiatry. 2001; 58 (4): 334-341.
  • Knott V. et al. EEG correlates of imagery-induced cigarette craving in male and female smokers. Addictive Behaviors. 2008; 33 (4): 616-621.
  • Koob G.F. et al. Role for the mesocortical dopamine system in the motivating effects of cocaine. NIDA research monograph. 1994; 145: 1-1.
  • Koob G.F., Volkow N.D. Neurocircuitry of addiction. Neuropsychopharmacology. 2010; 35 (1): 217-238.
  • Kufahl P.R. et al. Neural responses to acute cocaine administration in the human brain detected by fMRI. Neuroimage. 2005; 28 (4): 904-914.
  • Laruelle M. et al. SPECT imaging of striatal dopamine release after amphetamine challenge. Journal of Nuclear Medicine. 1995; 36 (7): 1182-1190.
  • Lehtinen I. et al. Individual Alcohol reaction profiles. Alcohol. 1985; 2 (3): 511-513.
  • Lehtinen I., Lang A.H., Keskinen E. Acute effect of small doses of alcohol on the NSD parameters (normalized slope descriptors) of human EEG. Psychopharmacology. 1978; 60 (1): 87-92.
  • Liu X. et al. Effect of cocaine-related environmental stimuli on the spontaneous electroencephalogram in polydrug abusers. Neuropsychopharmacology. 1998; 19 (1): 10-17.
  • London E.D. et al. Cocaine-induced redoppuction of glucose utilization in human brain): A study using positron emission tomography and -fluorodeoxyglucose. Archives of General Psychiatry. 1990; 47 (6): 567-574.
  • London E.D. et al. Morphine-induced metabolic changes in human brain): studies with positron emission tomography and fluorodeoxyglucose. Archives of General Psychiatry. 1990; 47 (1): 73-81.
  • Lukas S.E., Mendelson J.H., Benedikt R. Electroencephalographic correlates of marihuana-induced euphoria. Drug and Alcohol Dependence. 1995; 37 (2): 131-140.
  • Maas L.C. et al. Functional magnetic resonance imaging of human brain activation during cue-induced cocaine craving. American Journal of Psychiatry. 1998; 155 (1): 124-126.
  • Mansvelder H.D., McGehee D.S. Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron. 2000; 27 (2): 349-357.
  • Martinez D. et al. Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum. Biological Psychiatry. 2005; 58 (10): 779-786.
  • Mathew R.J. et al. Regional cerebral blood flow after marijuana smoking. Journal of Cerebral Blood Flow & Metabolism. 1992; 12 (5): 750-758.
  • McClure S.M., York M.K., Montague P.R. The neural substrates of reward processing in humans): the modern role of FMRI. The Neuroscientist. 2004; 10 (3): 260-268.
  • Mogg K. et al. Eye movements to smoking □ related pictures in smokers): relationship between attentional biases and implicit and explicit measures of stimulus valence. Addiction. 2003; 98 (6): 825-836.
  • Myrick H. et al. Differential brain activity in alcoholics and social drinkers to alcohol cues): relationship to craving. Neuropsychopharmacology. 2004; 29 (2): 393.
  • Nader M.A. et al. PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys. Nature Neuroscience. 2006; 9 (8).
  • Nader M.A., Czoty P.W. PET imaging of dopamine D2 receptors in monkey models of cocaine abuse): genetic predisposition versus environmental modulation. American Journal of Psychiatry. 2005; 162 (8): 1473-1482.
  • Nakamura H. et al. Activation of fronto-limbic system in the human brain by cigarette smoking): evaluated by a CBF measurement. The Keio Journal of Medicine. 2000; 49: A122-4.
  • Noldy N.E. et al. Quantitative EEG changes in cocaine withdrawal): Evidence for long-term CNS effects. Neuropsychobiology. 1994; 30 (4): 189-196.
  • Papageorgiou C.C. et al. Long-term abstinence syndrome in heroin addicts): indices of P300 alterations associated with a short memory task. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2004; 28 (7): 1109-1115.
  • Parsons O.A., Sinha R., Williams H.L. Relationships between Neuropsychological Test Performance and Event Related Potentials in Alcoholic and Nonalcoholic Samples. Alcoholism: Clinical and Experimental Research. 1990; 14 (5): 746-755.
  • Payer D.E. et al. Differences in cortical activity between methamphetamine-dependent and healthy individuals performing a facial affect matching task. Drug and Alcohol Dependence. 2008; 93 (1): 93-102.
  • Reid M.S. et al. Cocaine cue versus cocaine dosing in humans): evidence for distinct neurophysiological response profiles. Pharmacology Biochemistry and Behavior. 2008; 91 (1): 155-164.
  • Reid M.S. et al. Topographic imaging of quantitative EEG in response to smoked cocaine self-administration in humans. Neuropsychopharmacology. 2006; 31 (4): 872-884.
  • Risinger R.C. et al. Neural correlates of high and craving during cocaine self-administration using BOLD fMRI. Neuroimage. 2005; 26 (4): 1097-1108.
  • Ritz M.C. et al. Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science. 1987; 237: 1219-1224.
  • Robinson T.E., Berridge K.C. Incentive sensitization and Addiction. Addiction. 2001; 96 (1): 103-114.
  • Saletu-Zyhlarz G.M. et al. Differences in brain function between relapsing and abstaining alcohol-dependent patients, evaluated by EEG mapping. Alcohol and Alcoholism. 2004; 39 (3): 233-240.
  • Shufman E. et al. Electro-encephalography spectral analysis of heroin addicts compared with abstainers and normal controls. The Israel Journal of Psychiatry and Related Sciences. 1996; 33 (3): 196-206.
  • Sinha R. et al. Imaging stress-and cue-induced drug and alcohol craving): association with relapse and clinical implications. Drug and Alcohol Review. 2007; 26 (1): 25-31.
  • Smolka M.N. et al. Severity of nicotine dependence modulates cue-induced brain activity in regions involved in motor preparation and imagery. Psychopharmacology. 2006; 184 (3-4): 577-588.
  • Stein E.A. et al. Nicotine-induced limbic cortical activation in the human brain): a functional MRI study. American Journal of Psychiatry. 1998; 155 (8): 1009-1015.
  • Tanabe J. et al. Ventral striatal blood flow is altered by acute nicotine but not withdrawal from nicotine. Neuropsychopharmacology. 2008; 33 (3): 627-633.
  • Tapert S.F. et al. fMRI BOLD response to alcohol stimuli in alcohol dependent young women. Addictive Behaviors. 2004; 29 (1): 33-50.
  • Tapert S.F. et al. Neural response to alcohol stimuli in adolescents with alcohol use disorder. Archives of General Psychiatry. 2003; 60 (7): 727-735.
  • Teneggi V. et al. EEG power spectra and auditory P300 during free smoking and enforced smoking abstinence. Pharmacology Biochemistry and Behavior. 2004; 77 (1): 103-109.
  • Tiihonen J. et al. Acute ethanol-induced changes in cerebral blood flow. American Journal of Psychiatry. 1994; 151 (10): 1505-1508.
  • Volkow N.D. et al. Activation of orbital and medial prefrontal cortex by methylphenidate in cocaine-addicted subjects but not in controls): relevance to addiction. Journal of Neuroscience. 2005; 25 (15): 3932-3939.
  • Volkow N.D. et al. Acute effects of ethanol on regional brain glucose metabolism and transport. Psychiatry Research: Neuroimaging. 1990; 35 (1): 39-48.
  • Volkow N.D. et al. Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers): implications in addiction. American Journal of Psychiatry. 1999; 156 (1): 19-26.
  • Volkow N.D. et al. Brain DA D2 receptors predict reinforcing effects of stimulants in humans): replication study. Synapse. 2002; 46 (2): 79-82.
  • Volkow N.D. et al. Cerebral blood flow in chronic cocaine users): a study with positron emission tomography. The British Journal of Psychiatry. 1988; 152 (5): 641-648.
  • Volkow N.D. et al. Changes in brain glucose metabolism in cocaine dependence and withdrawal. The American Journal of Psychiatry. 1991; 148 (5): 621.
  • Volkow N.D. et al. Cognitive control of drug craving inhibits brain reward regions in cocaine abusers. Neuroimage. 2010; 49 (3): 2536-2543.
  • Volkow N.D. et al. Decreased brain metabolism in neurologically intact healthy alcoholics. The American Journal of Psychiatry. 1992; 149 (8): 1016.
  • Volkow N.D. et al. Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. Synapse. 1993; 14 (2): 169-177.
  • Volkow N.D. et al. Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects. Nature. 1997; 386 (6627): 830-833.
  • Volkow N.D. et al. Decreases in dopamine receptors but not in dopamine transporters in alcoholics. Alcoholism: Clinical and Experimental Research. 1996; 20 (9): 1594-1598.
  • Volkow N.D. et al. Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues. Neuroimage. 2008; 39 (3): 1266-1273.
  • Volkow N.D. et al. Effects of acute alcohol intoxication on cerebral blood flow measured with PET. Psychiatry Research. 1988; 24 (2): 201-209.
  • Volkow N.D. et al. Effects of chronic cocaine abuse on postsynaptic dopamine receptors. Am J Psychiatry. 1990; 147 (6): 719-724.
  • Volkow N.D. et al. High levels of dopamine D2 receptors in unaffected members of alcoholic families): possible protective factors. Archives of General Psychiatry. 2006; 63 (9): 999-1008.
  • Volkow N.D. et al. Imaging dopamine's role in drug abuse and addiction. Neuropharmacology. 2009; 56: 3-8.
  • Volkow N.D. et al. Imaging endogenous dopamine competition with raclopride in the human brain. Synapse. 1994; 16 (4): 255-262.
  • Volkow N.D. et al. Reduced metabolism in brain "control networks" following cocaine-cues exposure in female cocaine abusers. PloS one. 2011; 6 (2): e16573.
  • Volkow N.D. et al. Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D2 receptors. Journal of Pharmacology and Experimental Therapeutics. 1999; 291 (1): 409-415.
  • Volkow N.D. et al. Relationship between subjective effects of cocaine and dopamine transporter occupancy. Nature. 1997; 386 (6627): 827-830.
  • Volkow N.D., Fowler J.S. Addiction, a disease of compulsion and drive): involvement of the orbitofrontal cortex. Cerebral Cortex. 2000; 10 (3): 318-325.
  • Volkow N.D., Fowler J.S., Wang G.J. Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. Journal of Psychopharmacology. 1999; 13 (4): 337-345.
  • Wang G.J. et al. Dopamine D2 receptor availability in opiate-dependent subjects before and after naloxone-precipitated withdrawal. Neuropsychopharmacology. 1997; 16 (2): 174-182.
  • Warren C.A., McDonough B.E. Event-related brain potentials as indicators of smoking cue-reactivity. Clinical Neurophysiology. 1999; 110 (9): 1570-1584.
  • Waters A.J. et al. Attentional shifts to smoking cues in smokers. Addiction. 2003; 98 (10): 1409-1417.
  • Wexler B.E. et al. Functional magnetic resonance imaging of cocaine craving. American Journal of Psychiatry. 2001; 158 (1): 86-95.
  • Wrase J. et al. Development of alcohol-associated cues and cue-induced brain activation in alcoholics. European Psychiatry. 2002; 17 (5): 287-291.
Еще