Gender-dependent hemostasis profile in apparently healthy young people

The objective of the study is to reveal the parameters of red blood cells, rheology, endothelin level, Willebrand factor, tPA-PAI-1 complex, antithrombin III, procoagulantive mechanisms of the hemostatic system and fibrinogen in medical students in the process of learning, taking into account gender differences. Materials and Methods. We examined 100 relatively healthy people (50 men and 50 women who did not have any complaints, were not under regular medical checkup, and did not have any proven diagnoses). The absence of diseases was confirmed by medical documentation, since all study participants underwent an annual preventive examination for admission to study. The volunteers were 18-30 years old. Results. Women had a higher endothelin level if compared with healthy men, which led to less powerful vasoconstriction and increased procoagulant blood activity. At the same time, higher levels of both procoagulant, anticoagulant and fibrinolytic blood activity were recorded. A significantly lower concentration of the tPA-PAI-1 complex and a change in the vWF index were also noted. In addition, relatively healthy women showed greater activity of VIIIa factor, higher resistance of Va factor to active protein C, and significantly higher fibrin content if compared with healthy men.