New immunomorhpological diagnostic criteria of ileitis in patients with inflammatory bowel disease

Ileal biopsies of 50 patients, from them 18 with Crohn's disease, 11 - with inflammatory bowel disease unclassified and 21 - with not changed mucous membrane are studied. Immunohistochemical research with antibodies to Chromogranin A and CD3 is conducted. At Crohn's disease the number of neuroendocrine cells in one villus was 0 - 28 (mean - 3±8), at inflammatory bowel disease unclassified - 3 - 31 (mean - 15±8), in not changed mucous membrane - 1 - 19 (mean - 9±5). At calculation of quantity of neuroendocrine cells on all crypt it is revealed that at Crohn's disease the minimum and maximum values of the maintenance of these cells were 4 - 24 (mean - 13±5), at inflammatory bowel disease unclassified - 0 - 26 (mean - 14±8), in not changed mucous membrane - 1 - 26 (mean - 9±5). Number CD3+intraepitelial lymphocytes in one villus with the sizes 400 μm and less at Crohn's disease was 7 - 62 (mean - 23±11), at inflammatory bowel disease unclassified - 11 - 49 (mean - 24±8), in not changed mucous membrane - 3 - 50 (mean - 18±9)...