About risk factors of neural tube defects in hereditally extended marriage

Surveyed 50 families with a child with congenital malformations of the central nervous system. The analysis of the pedigree on the presence of congenital malformations of any localization and diseases, in the genesis of which lies hyperhomocysteinemia. Genealogy, morbidity analysis was carried out in all families, hereditary and family burdens were revealed. Families of sick children with hereditary diseases of various organs and systems with hyperhomocysteinemia in genesis (28 families, 56%) were identified based on the family history and genealogy, risk factors were identified in nine hereditary burdened families, of which two families still have related marriage, families surveyed without any hereditary burdens.