About genotoxicity of modified nuclosides

It was analysed the genotoxicity of synthetic modified analogs of the nucleosides: 1-b-Dribofuranozilbenzotriazol (I), 1-b-D-ribofuranozilbenzoimidazol (II), 1-b-D-eritrofuranozilbenzoimidazol (III). It was founded that all synthetic compounds induce the recessive and dominant lethal mutations of Drosophila melanogaster, inhibit the blasttransfomation of lymphocyte nucleoses in the periferic human blood, decrease the fertility of females and males of Drosophila melanogaster. The possibility of the influencing of synthetic compounds on the cell division is discussed.