Potential of spectral ellipsometry in studying the blood serum of chronic pancreatitis patients. Full factorial experiment

The purpose of work is identification of real opportunities of a method of an ellipsometriy for research of plasma of blood for diagnostics of chronic pancreatitis. Thus plasma is used in the form of a liquid phase. The experiment made with use of spectral ellipsometer on samples of plasma of blood of patients with chronic pancreatitis, led to important results. First of all the essential dispersion of polarizing corners Δ and Ψ on plasma samples is observed with a set length of a wave that points to good opportunities of a method in questions of diagnostics of chronic pancreatitis at different stages. Besides, the behavior of these corners in the spectral range of the device with all evidence indicates blanket existence on plasma samples. Thickness and optical parameters of this layer depend on expressiveness of a disease. The method of an ellipsometriy possessing supersensitivity to change of a condition of a surface, reacts to it noticeable change of measured polarizing corners Δ and Ψ which values, obviously, don't depend on a choice of model of a reflecting surface. In carried-out work at the first stage the model of a homogeneous environment is used. In this case we deal with effective index of refraction of n ef of plasma of the blood which behavior is also connected with expressiveness of a disease. Processing of results the ellipsometric of measurements is carried out (concerning parameters Δ, Ψ and n ef) by means of a statistical method of complete factorial experiment. As major factors of X 1, X 2, X 3 such symptoms of chronic pancreatitis, as fibrosis, pseudo-cysts and kaltsinats are considered. It is thus established that for the considered group of patients combinations of factors of X 1X 3 and X 1X 2X 3 are statistically significant. It means that the greatest influence on the optical parameters determined by a method of an ellipsometriya on samples of plasma of blood, has simultaneous effect of factors of X 1 and X 3 (fibrosis + kaltsinats), and also simultaneous action of all three factors (fibrosis + pseudo-cysts + kaltsinats).