Total coagulation activity of blood cells against the background of additional administration of black cumin oil

The aim of our study was to study the effect of black cumin oil (BCO) on the thromboplastic activity of whole cells. The results of the study showed that the thromboplastic activity of whole erythrocytes in animals of the experimental group was 18.4% lower than in the control group. The study of the coagulation properties of platelets revealed their decrease in animals of the experimental group by 9.3%. Thus, the previously identified limitation of lipoperoxidation processes caused by the introduction of BCO affects the thromboplastic activity of whole cells, and, consequently, on the rheology of blood and the maintenance of its hemostatic potential. The data obtained indicate that, by limiting the processes of lipoperoxidation, on the one hand, they reduce the expression of coagulatively active phospholipids on the cell surface, which increases the hemostatic potential of intact erythrocytes. On the other hand, the weakening of lipid peroxidation in erythrocytes under the influence of the studied mixed substance protects them from increased destruction and, consequently, reduces the possibility of cell participation in blood clotting.