Assessment of the airborne phthalate exposure on lung function of preschool and primary school children

He results of the studies of phthalates’ content in the indoor and outdoor air on the territory of pre-school and school educational institutions, the definition of phthalates metabolites in the urine and parameters of lung function of children attending these institutions are presented in the work. The HPLC/MS method detected the presence of 4 phthalates in 7 analyzed rooms and the air of pre-school and school facilities in the range 0.0002-0.00116 mg/m3 concentrations. The method of HPLC/MS/TFE metabolites detected the presence of phthalate (monometylphtalate, monobutylphtalate, monohexylilphtalate) in the urine of children in the concentration range of 0.00039-0.012 mg/m3. Analysis of dependencies of "the concentration of phthalate metabolites in the urine - the parameters of pulmonary function" revealed a statistically significant correlation coefficients (p