Estimation of bactericidal activity and cytokines secretion by leucocytes of the peripheric blood at early stage of development of the burn disease

In work are presented the levels of bactericidal activity of neutrophils and secretion of some intact cytokines and stimulated of E. coli by neutrophils and mononuclears of peripheric blood of burn patients at a stage of systemic inflammatory response (SIRS) syndrome with an estimation of dynamics of patients condition on clinical data, gravity of burn disease current, presence of complications and outcome. It is established, that at SIRS stage markers of lethal outcome of the victims, carried to serious sepsis, are: dysregulation of bacteri-cidal activity of neutrophils (prevalence extracellular killing of alive E. coli above intracellular); low levels TNF-a in supernatants of intact mononyclears at 24-hour incubation, INF--activated mononuclears and IL-10 (without dependence from stimulation) in comparison practically with all groups of research.