Оценка биологической безопасности графеновых наноструктур in vivo : обзор литературы
Автор: Раскоша О.В., Старобор Н.Н., Башлыкова Л.А.
Журнал: Известия Коми научного центра УрО РАН @izvestia-komisc
Статья в выпуске: 5 (51), 2021 года.
Бесплатный доступ
Наноматериалы на основе графена обладают уникальными физико-химическими свойствами, подходящими для различных приложений в электронике, телекоммуникациях, энергетике, биологии и медицине. Необходимым этапом исследований, посвященных возможности практического использования графеновых наноструктур, является оценка их токсического воздействия и биологической совместимости. В статье представлен обзор литературы по изучению биологической безопасности наноматериалов на основе графена с использованием модельных систем in vivo. Сделан вывод о необходимости более подробного изучения токсичности наноматериалов на основе графена с обязательным выявлением связи между их характеристикой и биологической эффективностью.
Графеновые наноматериалы, in vivo, токсичность, биологическая эффективность
Короткий адрес: https://sciup.org/149139323
IDR: 149139323 | УДК: 57.04:546.26-162-022.532-026.86:599.323(048.8) | DOI: 10.19110/1994-5655-2021-5-35-45
Assessment of biological safety of graphene nanostructures in vivo : literature review
Graphene is a flat monoatomic layer of carbon arranged in a two-dimensional crystalline structure. The active study of graphene is growing exponentially, attracting scientists from various fields of science. Graphene-based nanomaterials have unique physical and chemical properties suitable for diverse applications in electronics, telecommunications, energy, healthcare and ecology. There is also an increasing interest in the biomedical application of graphene nanomaterials. However, a significant obstacle to the wider practical use of graphene and materials based on it remains the lack of an unambiguous answer to the question of their potential danger. The paper presents a review of the literature on the study of the biological safety of graphene-based nano-materials in vivo using mice and rats as test objects, as a generally accepted human model. The scientific community has identified the need for a more detailed study of the toxicity of graphene and materials based on it, with the mandatory identification of the relationship between their characteristics and biological efficiency. In studies on the whole organism, the biological effect depends not only on the chemical nature of nanomaterials, but also on the dose, route of administration, the time and mode of exposure, as well as on the animals used for testing. In addition, given the possible toxic effect of graphene-based nanoparticles, it is necessary to investigate and critically assess the potential long-term risks. A detailed comprehensive assessment of the biological safety of graphene nanostructures will contribute to the advancement of knowledge necessary for the development of safe graphene-based technologies and products suitable for medical applications, and to minimize risks to human health.
Список литературы Оценка биологической безопасности графеновых наноструктур in vivo : обзор литературы
- Electric field effect in atomically thin carbon films / K.S. Novoselov, A.K. Geim, S.V. Moro-zov, D. Jiang, Zhang Y., S.V. Dubonos, I.V. Grigorieva, AA. Firsov // Science. 2004. Vol. 306. P. 666-669. DOI: 10.1126/science. 110 2896
- Graphene and graphene oxide: synthesis, properties, and applications / Y. Zhu, S. Murali, W. Cai, X.Li, J.W. Suk, J.R. Potts, RS. Ruoff // Advanced materials. 2010. Vol. 22. No. 35. P. 3903-3958. DOI: 10.1002/adma.201001068
- Graphene oxide induces dose-dependent lung injury in rats by regulating autophagy / L. Zhang, S. Ouyang, H. Zhang, M. Qiu, Y. Dai, S. Wang, Y. Wang, J.Ou // Experimental and therapeutic medicine. 2021. Vol. 462. P. 1-11. DOI: 10.3892/etm.2021.9893
- Feng L., Wu L., Qu X. New Horizons for Diagnostics and Therapeutic Applications of Graphene and Graphene Oxide // Advanced Materials. 2013. Vol. 25. P. 168-186. DOI: 10. 1002/adma.201203229
- Zhang X., Liang Т., Ma Q. Layer-by-layer assembled nano-drug delivery systems for cancer treatment. Drug Delivery. 2021. Vol. 28(1). P. 655-69. DOI: 10.1080/10717544.2021.1905 748.
- Graphene in mice: ultrahigh in vivo Tumor uptake and efficient photothermal therapy / K. Yang, S. Zhang, G. Zhang, X. Sun, S.-T. Lee, Z. Liu // Nano Lett. 2010. Vol. 10 (9). P. 3318-3323. DOI: 10.1021/nll00996u
- X-ray-induced nanoparticle-based photody-namic therapy of cancer / X. Zou, M. Yao, L. Ma, M. Hossu, X. Han, P. Juzenas, W. Chen // Nanomedicine. 2014. Vol. 9 (15). P. 2339-2351. DOI: 10.2217/nnm.l3.198
- Recent progress of graphene oxide-based multifunctional nanomaterials for cancer treatment / L. Liu, Q. Ma, J. Cao, Y. Gao, S. Han, Y. Liang, Т. Zhang, Y. Song & Yong et al. // Cancer Nano. 2021. Vol. 12 (18). DOI: 10.1186/sl2645-021-00087-7
- Langer R., Vacanti J. Advances in tissue engineering // J. of Pediatric Surgery. 2016. Vol. 51(1). P. 8-12. DOI: 10.1016/j.jpedsurg. 2015.10.022
- Graphene-Based Interfaces Do Not Alter Target Nerve Cells / A. Fabbro, D. Scaini, V. León, E. Vázquez, G. Cellot, G. Privitera et al. // ACS Nano. 2016. Vol. 10. No. 1. P. 615-623. DOI: 10.1021/acsnano.5B05647
- High-resolution mapping of infraslow cortical brain activity enabled by graphene micro-tran-sistors / E. Masvidal-Codina, X. Illa, M. Dasil-va et al. // Nature Mater. 2019. Vol. 18. P. 280-288. DOI: 10.1038/s41563-018-0249-4
- Аксенова Е.И., Камынина H.H., Маклакова ЮА. Биосенсорные системы в медицине: экспертный обзор. М.: ГБУ «НИИОЗММ ДЗМ», 2020. 20 с. Aksenova E.I., Kamynina N.N., Maklakova YuA. Biosensornie sistemy v medicine: eks-pertnii obzor [Biosensory systems in medicine: an expert review]. Moscow: Res. Inst, of Healthcare Organization and Medical Management of the Moscow Dept. of Healthcare, 2020. 20 p.
- Graphene oxide/hydroxyapatite composite coatings fabricated by electrochemical deposition / Y. Zeng, X. Pei, S. Yang, H. Qin, H. Cai, S. Ни, L. Sui, Q. Wan, J. Wang // Surface and Coatings Technology. 2016. Vol. 286. P. 72-79. DOI: 10.1016/j.surfcoat. 2015. 12.013
- Reduced Graphene Oxide Incorporated GelMA Hydrogel Promotes Angiogenesis For Wound Healing Applications / S.R.U. Rehman, R. Augustine, AA. Zahid, R. Ahmed, M. Tariq, A Hasan II Int. J. of Nanomedicine. 2019. Vol. 14. P. 9603-9617. DOI: 10.2147/IJN.S218120
- Bianco A. Graphene: Safe or Toxic? The Two Faces of the Medal // Angewandte Chemie International Edition. 2013. Vol. 52. P. 4986-4997. DOI: 10.1002/anie.201209099
- К rug H.F. Nanosafety Research - Are We on the Right Track? / Angewandte Chemie International Edition. 2014. Vol. 53. P. 12304-12319. DOI: 10.1002/anie.201403367
- Максимова P.M., Бурдов В А. Квантовая механика графена. Нижний Новгород: Нижегородский госуниверситет, 2019. 37 с. Maksimova G.M., Burdov VA. Kvantovaya mehanika grafena [Quantum mechanics of graphene]. Nizhni Novgorod: N.Novgorod State Univ., 2019. 37 p.
- Thermal Properties of PEG/Graphene Nano-platelets (GNPs) Composite Phase Change Materials with Enhanced Thermal Conductivity and Photo-Thermal Performance / H. Wang, H. Zhu, Y. Gu, X. Li, X. Mao // Applied Sciences. 2018. Vol. 8. P. 2613 (1-14). DOI: 10.3390/app8122613
- Surface engineering of graphene-based nanomaterials for biomedical applications / S. Shi, F. Chen, E.B. Ehlerding, W. Cai // Bioconjug chemistry. 2014. Vol. 25. P. 1609-1619. DOI: 10. 1021/bc500332c
- Kim J., Gurunathan S. Synthesis, toxicity, biocompatibility, and biomedical applications of graphene and graphene-related materials // Int. J. of Nanomedicine. 2016. Vol. 11. P. 1927-1945. DOI: 10.2147/IJN.S105264
- Graphene and graphene oxide as nanomaterials for medicine and biology application / 5. Priyadarsini, S. Mohanty, S. Muk-herjee, S. Basu, M. Mishra // J. of Nanostructure in Chemistry. 2018. Vol. 8. P. 123-137. DOI: 10. 1007/s40097-018-0265-6
- Toktam N.. Cousins B.G., Seifalian AM. Toxicology of chemically modified graphene-based materials for medical application // Archives of toxicology. 2014. Vol. 88. P. 1987-2012. DOI: 10.1007/s00204-014-l 361-0
- Recent advances in graphene-based nanomaterials: properties, toxicity and applications in chemistry, biology and medicine / J. Yao, H. Wang, M. Chen, Yang // Microchim Acta. 2019. Vol. 186. P. 395 (1-25). DOI: 10.1007/ s00604-019-3458-x
- Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment / B. Fadeel, C. Bussy, S. Merino, E. Vázquez, E. Flahaut, F. Mouchet et al. // ACS Nano. 2018. Vol. 12. P. 10582-10620. DOI: 10.1021/acsnano.8b04758
- Liao C., Li Y., Tjong S.C. Graphene Nanomaterials: Synthesis, Biocompatibility, and Cytotoxicity // Int. J. of Molecular Sciences. 2018. Vol. 19. P. 35-64. DOI: 10.3390/ijmsl9113 564
- Toxicology of graphene-based nanomaterials / G. Lalwani, M. D'Agati, A. M. Khan, B. Sitharaman // Advanced Drug Delivery Reviews. 2016. Vol. 105 (Pt B). P. 109-144. DOI: 10.1016/j.addr.2016.04.028
- Toxicity of graphene-family nanoparticles: A general review of the origins and mechanisms / L. Ou, B. Song, H. Lianh, J. Liu, X. Feng, B. Deng, T. Sun, L. Shoo // Part. Fibre Toxicol. 2016. Vol. 13. P. 57 (1-24). DOI 10.1186/ si 2989-016-0168-y
- Biocompatibility of graphene oxide / K. Wang, J. Rúan, H. Song, J. Zhang, Y. Wo, S. Guo, D. Cu // Nanoscale Research Letters. 2011. Vol. 6. P. 8 (1-8). DOI: 10.1007/sl 1671-010-9751-6
- The use of polyethylenimine-modified gra-phe-ne oxide as a nanocarrier for transferring hydrophobic nanocrystals into water to produce water-dispersible hybrids for use in drug delivery / L. Yan, Y.-N. Chang, L. Zhao, Z. Gu, X. Liu et al. 11 Carbon. 2013. Vol. 57. P. 120-129. DOI: org/10.1016/j.carbon.2013. 01.042
- Dose ranging, expanded acute toxicity and safety pharmacology studies for intravenously administered functionalized graphene nano-particle formulations / S. Kanakia, J.D. Tous-saint, S.M. Chowdhury, T. Tembulkar, S. Lee, Y.-P. Jiang R. Z Lin, KR. Shroyer, W. Moore, B. Sitharaman // Biomaterials. 2014. Vol. 35. P. 7022-7031. DOI: 10.1016/ j.biomaterials. 2014.04.066
- Influence of Polyethylene Glycol Coating on Biodistribution and Toxicity of Nanoscale Graphene Oxide in Mice after Intravenous Injection / B. Li, X. Zhang, J. Yang, Y. Zhang, W. Li, C. Fan, Q. Huang // Int. J. of Nanomedicine. 2014. Vol. 9. P. 4697-4707. DOI: 10.2147/IJN.S66591
- In Vivo Pharmacokinetics, Long-Term Biodistribution, and Toxicology of PEGylated Graphene in Mice / K. Yang, J. Wan, S. Zhang, Y. Zhang, S.-T. Lee, Z.Liu // ACS Nano. 2011. Vol. 5. P. 516-522. DOI: 10.1021/nnl024303
- Assessing in vivo toxicity of graphene materials: current methods and future outlook / Y. Ma, H. Shen, X. Tu, Z. Zhang // Nanomedicine. 2014. Vol. 9. No. 10. P. 1565-1580. h DOI: 10.2217/nnm.l4.68
- Nanotoxicity of graphene and graphene oxide / A.B. Seabra, A.J. Paula, R. de Lima, O.L. Alves, N. Duran // Chemical Research in Toxicology. 2014. Vol. 27. No. 2. P. 159-168. DOI: 10.1021/tx400385x
- Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge / V. Stone, M.R. Miller, M.J.D. Cli-ft, A. Elder, N.L. Mills, P. M0ller et al. // Environmental Health Perspectives. 2017. Vol. 125. P. 106002-1-106002-17. DOI: 10.1289/ EHP42
- Minimizing Oxidation and Stable Nanoscale Dispersion Improves the Biocompatibility of Graphene in the Lung / M.C. Duch, G.R.S. Budinger, Y.T. Liang, S. Soberanes, D. Urich, S.E. Chiarella, LA. Campochiaro et al. // Nano Letters. 2011. Vol. 11. P. 5201-5207. DOI: 10.1021/nl202515a
- Thrombus Inducing Property of Atomically Thin Graphene Oxide Sheets / S.K. Singh, M.K. Singh, M.K. Nay ah, S. Kumari, S. Shri-vastava, J.J A. Gracio, D. Dash // ACS Nano. 2011. Vol. 5. P. 4987-4996. DOI: 10.1021/ nn201092p
- Biodistribution and pulmonary toxicity of in-tratracheally instilled graphene oxide in mice / Li, J. Yang, Q. Huang, Y. Zhang, C. Peng, Y. Zhang, Y. He, J. Shi, W. Li, J. Hu // NPG Asia Materials, 2013. Vol. 5 (4). e44. DOI: 10.1038/am.2013.7
- Acute Oral Administration of Single-Walled Carbon Nanotubes Increases Intestinal Permeability and Inflammatory Responses: Association with the Changes in Gut Microbiota in Mice / H. Chen, R. Zhao, B. Wang, L. Zheng, H. Ouyang, H. Wang et al. // Advanced healthcare materials. 2018. Vol. 7. P. 1701313 (1-14). DOI: 10.1002/adhm.201701313
- Thrombus inducing property of atomically thin graphene oxide sheets / S.K. Singh, M.K. Singh, M.K. Nayak, S. Kumari, S. Shriva-stava, J.J. Gracio, D. Dash // ACS Nano, 2011. Vol. 5 (6). P. 4987-4996.
- Wang T., Zhu S., Jiang X. Toxicity mechanism of graphene oxide and nitrogen-doped graphene quantum dots in RBCs revealed by surface-enhanced infrared absorption spectroscopy // Toxicology Reports. 2015. Vol. 4 (4). P. 885-894. DOI: 10.1039/c4tx00138a
- Synthesis and cyto-genotoxicity evaluation of graphene on mice spermatogonial stem cells / E. Hashemi, O. Akhavan, M. Shamsara, M. Daliri, M. Dashtizad, A Farmany // Colloids and Surfaces B: Biointerfaces. 2016. Vol. 146. P. 770-776. DOI: 10.1016/j.colsurfb.2016. 07.019
- Cyto and genotoxicities of graphene oxide and reduced graphene oxide sheets on spermatozoa / E. Hashemi, O. Akhavan, M. Shamsara, R. Rahighi, A. Esfandiar, A.R. Tayefeh // RSC Advances. 2014. (4). P. 27213-27223. DOI: 10.1039/c4ra01047g
- Systematic evaluation of graphene quantum dot toxicity to male mouse sexual behaviors, reproductive and offspring health / D. Zhang, Z. Zhang, Y. Wu, K. Fu, Y. Chen, W. Li, M. Chu // Biomaterials. 2019. Vol. 194. P. 215-232. DOI: 10.1016/j.biomaterials.2018.12.001
- Xu S., Zhang Z., Chu M. Long-term toxicity of reduced graphene oxide nanosheets: Effects on female mouse reproductive ability and offspring development // Biomaterials. 2015. Vol. 54. P. 188-200. DOI: 10.1016/j .biomaterials.2015.03.015
- Effects of Graphene Oxide on the Development of Offspring Mice in Lactation Period / C. Fu, T. Liu, L. Li, H. Liu, Q. Liang, X. Meng // Biomaterials. 2015. Vol. 40. P. 23-31. DOI: 10.1016/j.biomaterials.2014.11.014
- Graphene Family Nanomaterials in Ocular Applications: Physicochemical Properties and Toxicity / S. Borandeh, V. Alimardani, S.S. Abolmaali, J. Seppala // Chemical Research in Toxicology. 2021. pubs.acs.org/crt P. A-Q. DOI: 10.1021/acs.chemrestox. 0c00340
- Exposure to Carbon Nanotube Material: Assessment of Nanotube Cytotoxicity Using Human Keratinocyte Cells / AA Shvedova, V. Castranova, E.R. Kisin, D. Schwegler-Berry, A.R. Murray, V.Z. Gandelsman, A. Maynard, P. Baron // J. of Toxicology and Environmental Health (Part A). 2003. Vol. 66. P. 1909-1926. DOI: 10.1080/713853956
- T Lymphocytes Dominate Local Leukocyte Infiltration in Response to Intradermal Injection of Functionalized Graphene-Based Nanomate-rial / G.F. Erf, D.M. Falcon, K.S. Sulli van, S.E. Bourdo II J. of Applied Toxicology. 2017. Vol. 37. P. 1317-1324. DOI: 10.1002/jat. 3492
- Synergistic antibacterial actions of graphene oxide and antibiotics towards bacteria and the toxicological effects of graphene oxide on human epidermal keratinocytes / T. Pulingam, K.L. Thong, J.N. Appaturi, N.I. Nordin., J.D. Ignatius, W.L. Chin, F.L. Bey // European J. of pharmaceutical sciences. 2020. Vol. 142. P. 1-10. DOI: 10.1016/j.ejps.2019.105087
- Mytych J., Wnuk M. Nanoparticle technology as a double-edged sword: cytotoxic, genotoxic and epigenetic effects on living cells // J. Biomater. Nanobiotechnol. 2013. Vol. 4. No. 1. P. 53-63. DOI: 10.4236/jbnb.2013.41008
- Degradation of mitochondria and oxidative stress as the main mechanism of toxicity of pristine graphene on U87 glioblastoma cells and tumors and HS-5 cells / S. Jaworski, B. Strojny, E. Sawosz, M. Wierzbicki, M. Grodzik, M. Kutwin, K. Daniluk, A. Chwalibog // J. of Biomaterials and Nanobiotechnology. 2019. Vol. 20. P. 650-667. DOI: 10.3390/ijms200 30650
- Reduced graphene oxide induces transient blood-brain barrier opening: An in vivo study / M.C. Mendonca, E.S. Soares, M.B. de Jesus, H.J. Ceragioli, M.S. Ferreira, RR Catharine, MA. Cruz-Höfling II J. Nanobiotechnol. 2015. Vol. 13. P. 78. DOI 10.1186/sl2951-015-0143-z
- Oxidative damage in the kidney and brain of mice induced by different nanomaterials / S. Shang, S.Y. Yang, Z.M. Liu, X. Yang // Front. Biol. 2015. Vol. 10. P. 91-96. DOI: 10.1007/ si1515-015-1345-3
- Toxic potential of materials at the nanolevel / A. Nel, T. Xia, L. Mädler, N. Li // Science. 2006. Vol. 311. P. 622-627. DOI: 10.1126/sci-ence.1114397
- Unraveling stress-induced toxicity properties of graphene oxide and the underlying mechanism / W. Zhang, C. Wang, Z. Li, Z. Lu, Y. Li, J.J. Yin et al. II Advanced Materials. 2012. Vol. 24. P. 5391-5397. DOI: 10.1002/adma.20 1202678
- Toxicity of Nanoparticles on the Reproductive System in Animal Models: A Review / R.D. Brohi, L. Wang, H.S. Talpur, D. Wu, FA. Khan, D. Bhattarai, Z.U. Rehman, F. Farma-nullah, L.J. Huo // Frontiers in Pharmacology. 2017. Vol. 8. P. 606. DOI: 10.3389/ fphar.2017.00606
- Antioxidant chemistry of graphene-based materials and its role in oxidation protection technology / Y. Qiu, Z. Wang, A.C.E. Owens, I. Kulaots, Y. Chen, AB. Kane, R.H. Hurt // Nanoscale. 2014. Vol. 6 P. 11744-11755. DOI: 10.1039/c4nr03275f
- Кудряшов Ю.Б. Радиационная биофизика (ионизирующие излучения) / Под ред. В.К. Мазурика, М.Ф. Ломанова. М.: ФИЗМАТ-ЛИТ, 2004. 448 с. Kudryashov Yu.B. Radiacionnaya biofizika (ioniziruyuschie izlucjeniya) [Radiation biophysics (ionizing radiation)] / Ed. V.K. Mazu-rik, M.F. Lomanov. Moscow: FIZMATLIT, 2004. 448 p.
- Gudkov S.V., Popova N.R., Bruskov V.l. Radioprotective substances: history, trends and prospects 11 Biophysics. 2015. Vol. 60. No. 4. P. 659-667. DOI: 10.1134/S0006350 9150 40120
- Reducing X-Ray Induced Oxidative Damages in Fibroblasts with Graphene Oxide / Y. Qiao, P. Zhang, C. Wang, L. Ma, M. Su // Nanoma-terials (Basel). 2014. Vol. 4. P. 522-534. DOI: 10.3390/nano4020522
- Clinically Approved Carbon Nanoparticles with Oral Administration for Intestinal Radi-oprotection via Protecting the Small Intestinal Crypt Stem Cells and Maintaining the Balance of Intestinal Flora / C. Wang, J. Xie, X. Dong, L. Mei, M. Zhao, Z. Leng, H. Hu, L. Li, Z. Gu, Y. Zhao // Nano Micro Small. 2020. Vol. 16. P. 1-14. DOI: 10.1002/smll.201906 915
- Monte Carlo-based calculation of nano-scale dose enhancement factor and relative biological effectiveness in using different nanoparticles as a radiosensitizer / M. Robatjazi, H.R. Baghani, A. Rostami, A. Pashazadeh // Int. J. of Radiation Biology. 2021. DOI: 10.1080/09 553002.2021.1934748
