Evaluation of the diagnostic significance of biochemical markers of endogenous intoxication and oxidative stress at hepatitis in cattle

Currently, hepatitis, which is an inflammation of the liver tissue, is a fairly common hepatopathology in cattle. The article presents the results of studies to determine the concentration of molecules of medium mass and lipid peroxidation products in the blood of cows with hepatitis. The obtained data indicates that in cattle with hepatitis, metabolism is disturbed, hepatocytes are destroyed, the detoxification function of the liver decreases, oxidative stress develops, which leads to the entry into the bloodstream of animals of a significant amount of medium molecular mass substances and products of lipid peroxidation. In acute hepatitis in cows, the toxic fraction of MSM 254 increases to a large extent, and the concentration of primary (diene conjugates) and secondary (malondialdehyde) products of lipid peroxidation increases approximately equally. Therefore, the concentration of medium mass molecules and lipid peroxidation products in the blood of cattle can be considered as diagnostic markers that can be crucial for identifying animals with acute hepatitis, and their determination during treatment will make it possible to more accurately assess the severity of the pathological course process and, if necessary, adjust therapy.