Evaluation of the functional activity of thrombocytes in acute coronary syndrome without ST segment elevation in patients of older age groups

The number of GPIIb-IIIa receptors and expression of P-selectin on the platelet’s surface was analyzed before and after activation of ADP, in patients with acute coronary syndrome without ST segment elevation. It was found that in patients over 60 years, the number of GPIIb-IIIa platelet’s receptors as before ADP activation was significantly higher than in patients under 60 years of age (7.19 (5.90, 8.70) MFI vs 5.91 (4.53, 6.29) MFI, p = 0.006) and after activation (11.7 (8.21, 13.6) MFI vs 6.33 (5.06, 6.92) MFI, p = 0.0001 ). Similar changes were observed in the evaluation of P-selectin expression. The values in elderly patients exceeded this one in younger patients (0.69 (0.30, 1.05) % vs 0.35 (0.09, 0.42), P = 0.008), as well as after activation (7.50 (2.92, 15.92) % vs 0.96 (0.59, 1.64) %, p = 0.0001). It”s indicates more severe activation of the platelets in patients of the older age group. The frequency of occurrence of the frailty in patients with acute coronary syndrome without ST segment elevation was determined, and its effect on the platelet aggregation capacity was analyzed. A more significant increase in the number of platelet GPIIb-IIIa receptors after the action of ADP was recorded in frailty patients (11.7 (6.78, 15.0) MFI vs (6.57 (6.05, 6.99) MFI, p = 0.02) and similarly P-selectin (4.03 (1.09, 16.99) % vs 1.51 (0.76, 2.23) % respectively, p = 0.03).