Evaluation of the immuno-physiological response of the organism of newborn calves to the application of sodium nucleinate and estron analogue to dry cows

The aim of the research was to study the formation of colostral immunity and nonspecific resistance of newborn calves in the early postnatal period of ontogenesis after the use of sodium nucleinate in combination with sinoestrol 2 % to pregnant cows. The objects of the study were 20 deep-calving black-and-white cows, selected on the principle of paired analogues, which were divided into 2 groups (control and experimental) of 10 animals each, and newborn calves obtained from them. For 3-9 days before calving, the cows of the experimental group were administered once, intramuscularly, 0,2 % aqueous solution of sodium nucleinate at a dose of 5 ml and an oil solution of sinoestrol 2 % at a dose of 1 ml. The cows of the control group were injected with 0.9 % sodium chloride solution. According to the results of the experiment, an increase in immunoglobulins in the colostrum of the first and second milking by 19,4 and 10,2 % was established. On the first day of life in the blood of calves, a higher number of erythrocytes by 8,5-9,2 %, hemoglobin by 20,1 % was noted, which indicates a more intense course of redox processes; an increase in the content of leukocytes in the blood by 11.6-29.9 % and the relative and absolute number of T-lymphocytes by 6.0-6.6 % and 27.1-52.7 %, respectively, indicates the development of the cellular link of the immune system. In combination with an increased content of gamma globulins in the blood and increased non-specific resistance, calves quickly adapted to environmental conditions and were resistant to non-communicable diseases.