Efficacy evaluation of new local hemostatic vancomycin-containing agent based on oxidized cellulose in an experiment

In the paper we presented the first results of an experimental study of the efficacy of a new topical hemostatic vancomycin-containing agent based on oxidized cellulose as a hemostatic agent for preventing median sternotomy complications. The study showed that the use of the new hemostatic agent lowered the intraoperative blood loss in laboratory animals (mini-pigs) in comparison with bone wax; it did not cause clinical and histological signs of inflammation, for antibacterial properties comparable to vancomycin pharmacy, and does not adversely affect the regeneration of bone tissue 3 weeks after surgery.