Evaluation of the clinical outputs of tissue regeneration in the surgery of tissue defects in the syndrome of the diabetic stop

Aim: evaluation of the effectiveness of various methods of surgical treatment of wound tissue defects in diabetic foot syndrome, based on the principles of evidence-based medicine and taking into account clinically relevant phenomena - outcomes based on a mathematical model for assessing efficacy. Materials and methods: Patients with diabetic foot syndrome who had wound defects of soft tissues and skin corresponding to the Wagner 2-4 classification who were on treatment at the center of the “Diabetic Foot” of Kazan in 2016 were included in the study. The patients were divided into two groups according to the procedure for closing the wound defect. Results and their discussions: The results of the treatment were evaluated on the basis of clinically meaningful outcomes for patients: favorable and unfa- vorable, as well as various indicators of relative and absolute risks and benefits for various wound healing methods. The conclusion: The use of modern bioplastic materials «G-DeRM» in the treatment of ulcerative defects of the diabetic foot syndrome is most justified and contributes to the epithelization of defects and the reduction of clinical manifestations of the disease, which leads to favorable outcomes in 100% of cases. When the defect is closed with autodermoplasty using a split free skin flap or using interactive dressings, the incidence of adverse clinical outcome was 16%.