Assessing breaches of biochemical indicators of the state of bone tissue in children under conditions the airborne impact priority of chemical factors in the zone of influence companies producing aluminum

According to the results of the research, it was found that children living in the zone of aerogenic aluminum exposure at a level of up to 0.00085 mg/(kg-day) showed an excess of aluminum in the bio-environments (in urine, 4.5 times higher than in children Group of comparison and 5.6 times higher than the reference level, in the blood - 1.3 times higher than in the children of the comparison group and 3 times higher than the reference level). A comparative analysis of the laboratory parameters studied revealed abnormalities that characterize the disturbance of the bone tissue state (increase in the level of ionized calcium in the blood, tartrate-resistant acid phosphatase, decrease in phosphorus and N-osteocalcin level in the blood serum), oxidative and antioxidant processes 8-hydroxy-2-deoxyguanosine in the urine, a decrease in the level of AOA in the blood plasma). The relationship between the studied biochemical indicators of negative effects and the concentration of aluminum in the biomeds (blood, urine) of the children examined was proved.