Evaluation of the antitumour activity of local intraperitoneal hyperthermia in a model of advanced High-Grade ovarian carcinoma in rats

In our study we carried out an exploratory assessment of the antitumor activity of hyperthermic intraperitoneal perfusion (HiPEP) with 0.9 % sodium chloride solution and compared it with the effect of a single normother-mic intraperitoneal (i.p.) administration of cisplatin in the maximum tolerated dose (MTD). Thirty-six mature female Wistar rats with transplanted i.p. syngeneic ovarian carcinoma were randomized into three groups: control group (2 ml of 0.9 % sodium chloride i.p. at room temperature, n=12); cisplatin group (cisplatin 4 mg/ kg i.p. at room temperature, n=12); HiPEP group (open i.p. perfusion with 0.9 % sodium chloride solution at a temperature of 40,5-41,5 °C for 45 minutes, n=12). The primary endpoint was the overall survival (OS) of the animals in each of the three groups. The total peritoneal cancer index (PCi), weight and degree of ascites haemorrhagia were assessed at autopsy. The median OS in the control group, HiPEP, and cisplatin was 19, 39, and 40 days, respectively (log-rank test р