The methicillin-resistance measure of staphylococci clinical strains

Staphylococci play a great role in the emergence of various human illnesses. The most actual are infections caused by methicillin-resistant staphylococci. The study of methicillin susceptibility as a polyresistance marker includes the definition of the minimum inhibitory concentration (MIC) of antibiotic which in vitro fully suppresses the visible growth of microorganisms in the standard experiment conditions and is expressed in absolute figures (mg/l or mkg/ml). The aim of the research is the measure of MIC methicillin (oxacillin) for the clinical strains of staphylococci isolated from different clinical specimens and comparative analysis antibiotic's MIC for Staphylococcus aureus and coagulase-negative staphylococci (CNS). The result of the research is the determination of the oxacillin concentration preventing growth of the methicillin-resistant clinical strains of S.aureus and CNS which were detected from different profile hospitals of Saratov - general hospital №2, maternity hospital №6, children's regional hospital and centre of combustiology. The methicillin-resistant of the staphylococci clinical strains in the Saratov region has not been investigated before.