Assessment of free circulating DNA level and nucleotide profile at arterial hypertension

Arterial hypertension (AH) refers to socially significant diseases which cause a high level of primary disability and mortality. Identification of this pathology predictors, such as free circulating DNA (fc-DNA) level in blood, can provide early disease diagnostics, effective treatment, and, finally, a relatively favorable prognosis.Aim: To study fc-DNA level and nucleotide profile in blood plasm in patients with hypertension.Material and Methods. Study included 60 persons: 20 patients with stage II hypertension (group Hypertension II), 20 patients with stage III hypertension (group Hypertension III) and 20 healthy people (Control group). For fc-DNA isolation diaGene kit had been used. Obtained DNA samples were analyzed by liquid chromatography using FPLS® System (Sweden).