Assessment of the severity of connexin 43 expression in the myocardium in acute ischemia in experiment

Aim. The article deals with expression of connexin 43 in the myocardium in experimental modeling of acute ischemia of the heart muscle. Methods. The results of morphodynamics analysis of acute focal myocardial damage, as well as connexin 43 expression in the intercellular contacts of the myocardium during experimental modeling of acute ischemia in laboratory animals (n=95) are presented. Acute ischemia was induced by occlusion under local hyperthermic exposure of the left coronary artery. Myocardial samples were drawn for study following the withdrawal of animals from the experiment in 1,3,6,12,18,24 hours. Results. The expression of connexin 43 in acute ischemia in 3, 6 and 12 hours after occlusion of the left coronary artery in ischemic areas has a statistically significant difference as compared to that of the control group, p