Ограниченный протеолиз как способ снижения аллергенности запасных глобулинов семян

Автор: Кердиварэ А.М.

Журнал: Сельскохозяйственная биология @agrobiology

Статья в выпуске: 3 т.53, 2018 года.

Бесплатный доступ

По данным SDAP (структурная база данных аллергенных белков), запасные 11S и 7S глобулины семян арахиса, сои и некоторых других растений являются аллергенами. Структурной основой доменов двудоменных субъединиц 11S и 7S глобулинов служит β-баррель, соединенный с группой α-спиралей. В процессе эволюции в аминокислотных последовательностях запасных глобулинов за пределами структурного модуля β-баррель-α-спирали появились протяженные неупорядоченные вставки с повышенной чувствительностью к протеолитической атаке. Эти вставки определяют закономерности ограниченного протеолиза запасных глобулинов в прорастающих семенах и in vitro. В настоящем обзоре анализируются экспериментальные данные, полученные при исследовании ограниченного протеолиза запасных глобулинов семян арахиса (Arachis hypogaea L.), сои (Glycine max L.) и некоторых других растений. Установлено, что ограниченный протеолиз 11S глобулина арахиса (A. Cherdivară с соавт., 2017) приводит к разрушению С-концевой области a-цепей, включая участок, образующий группу a-спиралей...

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Запасные глобулины семян, протеолиз, аллергенность, ige эпитопы, арахис, соя

Короткий адрес: https://sciup.org/142216550

IDR: 142216550 | DOI: 10.15389/agrobiology.2018.3.475rus

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