Oxidative stress and antioxidant protection in people of various age under contact with adverse occupational factors

Free radical oxidation and antioxidant protection system has been examined for decades. However, experts still haven't been able to determine cause-and-effect relations between oxidative stress, age, working conditions, and a risk of functional and organic disorders that can develop in a human body. Our research goal was to detect peculiarities related to age dynamics of integral parameters that describe oxidative stress and total antioxidant capacity of blood serum; to assess their changes depending on impacts exerted by adverse occupational factors on a worker's body. 244 people aged from 18 to 65 were under observation; they all had physical loads at their workplaces and contacted adverse chemicals. These people underwent regular medical check-ups at a consultancy polyclinic of the Rospotrebnadzor's Nizhniy Novgorod Scientific Research Institute for Hygiene and Occupational Pathology. The first stage in the research involved mass screening aimed at detecting parameters related to oxidative stress and total antioxidant capacity of blood serum in all the examined people...