Cyclosporine A determination in human blood serum for therapeutic monitoring
Автор: Fedorova G.A., Podolskaya E.P., Novikov A.V., Lutvinsky yА. I., Krasnov N.V.
Журнал: Научное приборостроение @nauchnoe-priborostroenie
Рубрика: Масс-спектрометрия для биотехнологии. Интерпретация данных, методология, применение
Статья в выпуске: 4 т.18, 2008 года.
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New economical HPLC-method for cyclosporine A determination in patient blood serum has been proposed. Chromatography analysis was carried out on liquid chromatograph "Milichrom A02". For cyclosporine A peak identification and its homogeneity confirmation spectral ratios and on line LC-MS complex were used. The method allows determination of cyclosporine A in 100-400 ng/ml range with no more than 15 % error. Results of determination are used for therapeutic monitoring of cyclosporine A in oncology department of pediatric clinic.
Короткий адрес: https://sciup.org/14264568
IDR: 14264568
