The determination of chronic toxicity of new preparation "Vetom 21.77" on mice

The research objective was studying the main toxic ef-fects of new preparation "Vetom 21.77" on the basis of nema-tophage mushroom of Duddingtonia flagrans, struck target organs, latent period of the development and reversibility of effects. 5 groups (control and 4 experimental) having 20 mice in each were created. The experiment was made on the basis of Research Veterinary Laboratory of Agroscience and Tech-nology Park at the State University of Shakarim (Families, Kazakhstan). To experimental groups "Vetom 21.77" was appointed orally in the doses 2, 5, 50 and 300 mkl/kg masses daily for 6 months; in control group the preparation was not applied. For the results accounting of performed daily clinical examination, weekly weighing, registered the gain of absolute weight; studied the influence of the preparation on hematolog-ic indicators and carried out the morphometry of separate internal to research and through 1,5; 3; 4 and 6 months after application of the preparation. By the results of the research it was found out that at long using in the doses of 2, 5, 50 and 300 mkl/kg weight "Vetom 21.77" had no toxic impact on the organism of mice, i.e. absolute safety of animals was detect-ed. In the animals of experimental groups high gain of live weight was observed. According to the physiological state, hematological indices and morphometric parameters of stud-ied organs, there were no deviations from the norm in the treatment groups, i.e. Vetom 21.77 was defined as the fourth toxicity class drug - 'low-hazard substances'.