Determination of medicinal stability of microbacteria of tuberculosis to linarol F-1

The effectiveness of any anti-tuberculosis drug is assessed not only by the presence of bactericidal and bacteriostatic activity, but also by the ability to prevent the development of drug resistance. The purpose of this work was to study the bacteriostatic activity of a new preparation of Linarol F-1 belonging to the group α, ω-bis (amido- and hydrazidomethylsulfinyl- and sulfonyl) alkanes, with respect to various strains of mycobacterium tuberculosis. It was found that Linarol F-1 has a pronounced inhibitory (H37Rv, M. bovis 14) action on the reference and drug-resistant strains of mycobacteria, but does not have a specific effect on atypical strains (M. avium and M. terrae) at the concentration (10 μg / ml medium).