Determination of significant diagnostic criteria for the development of primary open-angle glaucoma based on a comprehensive statistical analysis of biomechanical and hemodynamic parameters of the eye

A complex statistical (correlation, discriminant, factorial) analysis of a set of parameters - biomechanical characteristics of the corneoscleral shell of the eye, hemodynamic parameters and perimetric indices, determined during examination of 110 eyes, including 69 eyes with various stages of primary open-angle glaucoma (POAG) and 41 eyes without ophthalmopathology - was carried out. Significantly correlated parameters characteristic of a particular stage of POAG were identified. The set of identified correlations characterizes progressive glaucoma damage as a process associated with a simultaneous change in the biomechanics of the eye shells and the scleral lamina cribrosa, as well as the blood supply to the choroid and retina, which, apparently, underlies the gradual deterioration of its photosensitivity and changes in the visual field. It was found that correlations within groups of patients with various stages of POAG change significantly with the progression of glaucomatous process, and, possibly, reflect the change in the contribution of biomechanical and hemodynamical disorders to the development of glaucomatous lesion at the corresponding stage of its development.