Organ-preserving treatment for early stage invasive cervical adenocarcinoma

From 2005 to 2009, 54 cervical carcinoma patients were followed up at the P.A. Gertsen MORI (Moscow) after modified radical abdominal trachelectomy (RAT), which was performed in 74,1 % of cases with squamous cell carcinoma, in 22,2 % of cases with adenocarcinoma and in 3,7 % of cases with clear cell adenocarcinoma. Stage IA1 cervical cancer with lymphovascular space involvement was diagnosed in 27,8 % of patients, stage IA2 in 25,9 %, stage IB1 in 38,9 %, stage IB2 in 3,7 %, and stage IIA in 3,7 % of patients. The follow-up time after RAT was from 1 to 49 months (medium 20 months). Recurrence occurred in 2 squamous cell carcinoma patients (3,7 %) 4 and 5 months after surgery. Considering small number of patients, differences in recurrence between squamous cell carcinoma and adenocarcinoma were not considered as significant. Radical trachelectomy was found to be effective for early stage invasive cervical adenocarcinoma. No convincing findings on more unfavorable prognosis for adenocarcinoma compared to squamous cell carcinoma of the cervix were obtained. The specific feature of adenocarcinoma is likely to be local recurrence but further studies are required to confirm this statement.