Основанное на методе Монте-Карло моделирование временных функций рассеяния точки и функций чувствительности для мезоскопической время-разрешенной флуоресцентной молекулярной томографии

Основанное на методе Монте-Карло моделирование временных функций рассеяния точки и функций чувствительности для мезоскопической время-разрешенной флуоресцентной молекулярной томографии

Автор: Самарин С.И., Коновалов А.Б., Власов В.В., Соловьев И.Д., Савицкий А.П., Тучин В.В.

Журнал: Компьютерная оптика @computer-optics

Рубрика: Дифракционная оптика, оптические технологии

Статья в выпуске: 5 т.47, 2023 года.

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В статье описан алгоритм программы TurbidMC, реализующей пертурбационный метод Монте-Карло и предназначенной для моделирования временных функций рассеяния точки и функций чувствительности для задач время-разрешенной флуоресцентной молекулярной томографии (FMT). Программа ориентирована на работу с конкретным ранее опубликованным методом FMT ([22] в списке литературы), определяющим специфику расчета функций чувствительности. Согласно этому методу обратная задача изначально решается относительно обобщенной функции распределения параметров флуоресценции, а затем уже выполняется разделение распределений коэффициента поглощения флуорофора и времени жизни флуоресценции. Корректность работы программы проверена сравнением тестовых расчетов флуоресцентных временных функций рассеяния точки с данными эксперимента по сканированию фантома с флуорофором трехканальным зондом в мезоскопическом режиме обратного рассеяния. Также приведен пример восстановления распределений параметров флуоресценции, подтверждающий корректность расчетов функций чувствительности.

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Программа turbidmc, метод монте-карло, флуоресцентная молекулярная томография, временные функции рассеяния точки, функции чувствительности, коэффициент поглощения флуорофора, время жизни флуоресценции

Короткий адрес: https://sciup.org/140301852

IDR: 140301852   |   DOI: 10.18287/2412-6179-CO-1295

Список литературы Основанное на методе Монте-Карло моделирование временных функций рассеяния точки и функций чувствительности для мезоскопической время-разрешенной флуоресцентной молекулярной томографии

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