Main areas in the treatment of non-alcoholic fatty liver disease

The treatment of non-alcoholic fatty liver disease (NAFLD) is inextricably linked with pathogenesis. An individual approach is recommended to lifestyle change. The hypocaloric diet and increased physical activity are the foundation of weight loss program. The main directions in the pharmacological treatment of NAFLD are prescription of drugs that reduce weight, increase the tissues sensitivity to insulin; normalize lipid levels and blood transaminase; correct the intestinal microflora. Currently orlistat is used for obesity treatment. The application of pharmacological agents is grounded, it has a positive impact on tissues sensitivity to insulin - insulinsensitizers. While a combined prescription of statins and UDCA, the lipid spectrum indicators normalize without increase of the transaminasis level. The use of œ-3 fatty acids is justified in patients with NAFLD and hypertriglyceridemia. The essential phospholipids (EFL) positively affect on the metabolism of lipids and proteins and detoxifying function of the liver. To correct the intestinal microflora, considering as-pects of the NAFLD pathogenic development, the use of probiotics is justified. The obetiholic acid is the promising medicinal preparation for NASH treatment.