Peculiarities of hemocoagulative disorders in patients with a syndrome of critical limbischemia in combination with diabetes mellitus

Treatment of patients with critical ischemia is an urgent issue of modern vascularsurgery in connection with unsatisfactory results of treatment. When combined with criticalischemia and diabetes mellitus during the year, 40-50% of patients undergo amputations witha mortality rate of 20-25%. In the article the results of investigation of hemostasis system in233 patients with critical ischemia in combination with diabetes mellitus and without it areconsidered. In critical ischemia, an increase in the level of fibrinogen, D-dimer, soluble fibrinmonomer complexes, PAI-I activity, decreased activity of protein S and thrombomodulin (p