Peculiarities of immune regulation and genetic polymorphism in urban population exposed to heavy metals

The results of the study of immune regulation in the urban population exposed to heavy metals showed an increase in the production of serum immunoglobulins IgM and IgA relative to the levels in the comparison group by 1.16 and 1.29 times, respectively, an increase in specific sensitization in the concentration of IgG antibodies to aluminum and lead in 69.4% of the examined population when compared with reference values, specific IgE antibodies to manganese by 1.63 times and IgE to chromium by 2.60 times relative to the comparison group. The reference values were exceeded by the level of regulatory CD4+CD25+CD127-lymphocytes, also significant by 2.62-3.13 times relative to the indicators of the comparison group, as well as the enhanced content of proinflammatory immune mediators IL-1beta and IL-8 in 4.45 and 1.47 times, respectively, relative to the comparison group. The increase in individual genetic variability in the examined group is associated with high frequency of the minor allele in the genes of detoxication and immune regulation us CYP1A1, CPOX, FOXP3 by 1.27, 1.33, 1.8 times, respectively, compared to the comparison group with an increase in the incidence of the heterozygous variant of the genotype, as well as the emergence of the mutant TLR4 genotype in 8% of the observed population group. The identified features can be used as immunogenetic marker indicators associated with the contamination of biological media by chemical factors under conditions of specific environmental exposure.