Features of change of cytokines in chronic purulent wounds

The aim of the study was to study the features of changes in the content of cytokines in chronic purulent wounds. In the washings of postoperative and purulent wounds, pro-inflammatory - interleukin-1beta (IL 1beta), tumor necrosis factor-α (TNF-α), and anti-inflammatory - interleukin-10 (IL-10), secretory Ig A, as well as transforming growth factor -β1 (TGF-β) by ELISA. The following results were obtained: in postoperative wounds, the indicators of pro-inflammatory interleukins were lower than anti-inflammatory interleukins and transforming factor β. At the same time, in chronic purulent wounds, there was a significant increase in pro-inflammatory interleukins and a decrease in anti-inflammatory interleukins, as well as transforming factor β, compared with those of postoperative wounds. Thus, a pronounced imbalance is created and an imbalance of cytokines of pro-inflammatory and antiinflammatory interleukins is noted. This helps to reduce the healing and chronicity of the inflammatory process of chronic purulent wounds.