Features of change in the content of proteases and proteases inhibitors in chronic purulent wounds

The work studied the features of changes in the content of proteases and protease inhibitors in chronic purulent wounds. It was concluded that in postoperative wounds, the indicators of general proteolytic activity and antiproteolytic activity do not differ significantly, there is an equilibrium between proteases and protease inhibitors, which can presumably be regulated by local mechanisms. In chronic purulent wounds, the total proteolytic activity is significantly higher than that of postoperative wounds. At the same time, the antiproteolytic activity is significantly lower than the general proteolytic activity, as well as lower than the antiproteolytic activity of postoperative wounds, which creates a pronounced imbalance between proteases and protease inhibitors and the chronicization of the inflammatory process in purulent wounds with the involvement of both local and systemic mechanisms of regulation.