Features of Klotho protein expression in the rat brain in experimental modeling of type 1 diabetes mellitus

Purpose of the study. Analysis of the correlation between the nature and degree of pathomorphological changes and Klotho protein expression in various parts of the brain during experimental reproduction of streptozotocin-induced diabetes mellitus. An experimental study was carried out on 30 white outbred laboratory female rats at the age of 12 months. Modeling streptozotocin-induced DM lasting 6 months. A significant decrease in the immunohistochemical expression of Klotho protein in neurons and ependymocytes of the brain, even in the absence of noticeable morphological changes, allows us to consider Klotho protein as marker of early cerebral complications of diabetes mellitus, and its deficiency plays a significant role in the development of diabetic encephalopathy.