Characteristics of electrophoretic mobility of red blood cells in patients on long-term hemodialysis

Objective: to analyze the electrophoretic properties of erythrocytes in patients receiving programmed hemodialysis treatment. Material and methods. The study included 100 patients with an established diagnosis of chronic kidney disease, stage 5D, receiving treatment with chronic (long-term) hemodialysis. Control group was composed of 17 healthy blood donors. Evaluated indicators of the electrophoretic activity of erythrocytes: vibration amplitude, proportion of motile cells, ellipticity and aggregation index. Results. In comparison with the control group, there were revealed significant changes in the amplitude of oscillations and the proportion of motile cells (p 0.001). No significant gender- defined differences were observed (p 0.05). Significant age differences between young adults and senior adults groups (p=0.048) were observed in the average vibration amplitude, and ellipticity between the middle-aged and senior (p=0.040), old and senior (p=0.035) adults groups. According to the duration of hemodialysis treatment, a decrease in the amplitude of fluctuations to the maximum from the minimum period was revealed: less than 1 year (p=0.029); 1 year (p=0.035), the indicators of the aggregation index have the highest values in the groups with the minimum (p=0.044) and maximum (p=0.035) periods of dialysis. Conclusion. In patients on long-term hemodialysis, the amplitude of red blood cells oscillations is significantly reduced with strong decreasing tendency associated with long duration of chronic hemodialysis treatment.