The features of endothelial dysfunction in chronic alcoholism

Endothelial dysfunction was studied in 34 patients with chronic alcoholism. The concentration of nitric oxide (NO) in blood serum was defined by enzymatic photometric method using a set of firm BCM Diagnostics reagents, USA. Endothelin#1 (ET#1) was examined by solid#phased method using Biomedica set of reagents, Austria. Endothelium vasodilatation was investigated by D. Celermaejer's and coauthors' technique. They have revealed elevated levels of NO and ET#1 in 76.5% patients with chronic alcoholism and simultaneous decrease in level of NO and ET#1 in 8.8% patients, decrease in level of NO and increase of ET#1 in 5.9% patients. In the initial state the diameter of a humeral artery in patients with chronic alcoholism doesn't differ from healthy ones. In flow#dependent vasodilatation the increase in diameter of a humeral artery was 6% (p=0.012), what is lower, than in healthy ones. The decrease of a humeral artery diameter has been registered in 20.6% patients. The sensitivity indicator of endothelin of a humeral artery to pressure of shift is lowered in patients with chronic alcoholism (p