Особенности канцерогенеза аденокарциномы толстой кишки

Особенности канцерогенеза аденокарциномы толстой кишки

Автор: Раскин Г.А., Петров С.В., Орлова Р.В.

Журнал: Сибирский онкологический журнал @siboncoj

Рубрика: Обзоры

Статья в выпуске: 4 (70), 2015 года.

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Рак толстой кишки - одна из наиболее распространенных форм злокачественных опухолей, занимающая лидирующие в мире позиции по летальности от рака. Выделяют четыре основных пути канцерогенеза аденокарциномы толстой кишки: трансформация аденомы в карциному; HNPCC (наследственный неполипозный рак толстой кишки); развитие рака «de novo»; трансформация хронического колита. Во всех из них, кроме синдрома Линча, все больше внимания уделяют стволовым ткань-коммитированным клеткам как мишеням мутаций и источнику злокачественных опухолей. Впоследствии возникающие из них стволовые раковые клетки рассматривают как причину химиорезистентности опухолей, развития рецидивов и метастазов. Таким образом, изучение данной популяции клеток может кардинально изменить подходы к лечению пациентов с аденокарциномой толстой кишки.

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Аденокарцинома толстой кишки, канцерогенез, стволовые клетки

Короткий адрес: https://sciup.org/14056565

IDR: 14056565

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