Peculiarities of bronchial asthma clinical course in smokers with small airway diseases

The literature review provides up-to-date information about the clinical course of bronchial asthma (BA) in smokers with small airway diseases. Special attention is paid to the combination of bronchial asthma and chronic obstructive pulmonary disease (COPD), namely asthma-COPD overlap syndrome (ACOS). According to literature data, in case of small airway duseases exacerbations are more often and severe in smokers with BA and ACOS. Besides, disease prognosis worsens due to reduction in the efficacy of a baseline therapy.