Peculiarities related to combined effects produced by chemical allergens mixture

Workers employed at chemical productions run risks of occupational allergic diseases with chemical etiology. These risks should be assessed and relevant prevention activities are to be substantiated; in this respect it is vital to reveal essence, peculiarities, and mechanisms of hyperimmune response when a body is exposed to a mixture of chemicals with various allergenic and toxic properties. We performed a series of experiments to examine allergenic properties of 57 various chemical mixtures and their separate components; the experiments involved modeling of intradermal introduction in standard doses into albino guinea pigs (ears) or into white mice (bases of tails), the substances were mixed with complete Freund's adjuvant. The obtained results allowed to reveal that intensity of allergenic activity shown by chemical mixtures was determined both by intensity of allergenic properties possessed by specific components in a mixture and by additivity of their immunomodulating effects under combined exposure...