Marginal dehydration of follicular fluid in patients with IVF and ET and endocrine disorders

The aim of the paper is to identify the characteristics of follicular fluid (VF) structural composition using marginal dehydration method in patients with endocrine disorders and assisted reproductive technology (ART) for infertility treatment. Materials and Methods. By means of marginal dehydration method the authors examined VF structural composition in 247 patients with tubal-endocrine infertility genesis. All the women were enrolled in IVF and PE programs. Among them, patients with endocrine disorders were identified (149 women). Results. When studying the VF morphology by marginal dehydration method, the authors identified specifics of local VF organization in various forms of endocrine infertility. According to the local organization structure, the intensity of proliferative and destructive processes in the follicle was determined, and local ovarian homeostasis was assessed. These compositional peculiarities allowed us to suggest the possibility of using typical markers to predict outcomes of ART technologies and to personalize therapeutic approaches.