Features of metabolism of blood lymphocytes in patients with acromegaly

Authors studied the lymphocytes metabolism in patients with active acromegaly. The state of a number of metabolic processes in lymphocytes under acromegaly is characterized by high intensity of intermediators formation for macromolecular synthesis and aerobic process while decreasing the activity of glutathionedependent antioxidant system. Acromegaly also causes the disconnection between the high level of oxidation reaction in Krebs cycle and ADP phosphorylation leading to depression of ATP formation and cell breath insufficiency. These changes in intracellular metabolism of blood lymphocytes in acromegalics correspond to functional reactivity disorders of immune cells and may appear as metabolic basis of oncological complication in acromegaly.