Features of indexes of the peroxidase of the thyroid gland at different types of craws

Developed at the Department of Histology DSMU histochemical method of detecting activity thyroperoxidase (IPO) (invention, foreground number 2015054203 from 16.12.2015) conducted a study to determine its capabilities when establishing a functional state of the thyroid gland (TG). It was found that the enzyme activity was determined in the follicular thyrocytes and varies considerably in various pathological conditions the organ. In particular, in histochemical preparations thyroid patients with diffuse toxic goiter IPO activity in the wall of the follicles and foci of adenomatous interfollicular high. It is characterized by epithelialprotrusion with marked activity in peripheral thyrocytes. In diseases of the thyroid gland in the stage euthyrosis enzyme activity in follicular thyrocytes moderate. The content of the enzyme significantly reduced by the macro and micro follicular colloid goiter and autoimmune thyroiditis in the stage of hypothyroidism was determined. It is concluded that the results of the proposed histochemical method for determining the activity of IPO allow pathologists to complement morphological conclusion functional.